Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004;53:1459–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Teuber SS, Beyer K. IgG to foods: a test not ready for prime time. Curr Opin Allergy Clin Immunol. 2007;7:257–8.
Article
PubMed
Google Scholar
Wuthrich B. Unproven techniques in allergy diagnosis. J Investig Allergol Clin Immunol. 2005;15:86–90.
CAS
PubMed
Google Scholar
Ali A, Scoulios N, Ten N. A National Assessment of the usage, cost, and reimbursement of unconventional medical laboratory tests. J Altern Complement Med. 2014;20:A3–A4.
Fell PJ, Srn SS, Brostoff J. Cellular responses to food in irritable bowel syndrome- an investigation of the Alcat test. J Nutr Med. 1991;2:143–9.
Google Scholar
Sangberg DH. A comparison of the ALCAT test for food reactions amongst 2 population sub-groups. Annals of Allergy. 1989;62:271.
Google Scholar
Mylek D. ALCAT Test results in the treatment of respiratory and gastrointestinal symptoms, arthritis, skin and central nervous system. Rocz Akad Med Bialymst. 1995;40:625–9.
CAS
PubMed
Google Scholar
Akmal M, Khan SA, Khan A. The Effect of the ALCAT Test diet therapy for food sensitivity. Middle East J Fam Med. 2009;7
Angelini F, Marzatico F, Stesina G, Stefanini L, Bonuccelli A, Buonocore D, Rucci S, Tencone F. Rational management of food intolerance in elite soccer club. J Int Soc Sports Nutr. 2011;8:36.
Article
Google Scholar
Kleine-Tebbe J, Herold DA. Inappropriate test methods in allergy. Hautarzt. 2010;61:961–6.
Article
CAS
PubMed
Google Scholar
Wuthrich B. History of food allergy. Chem Immunol Allergy. 2014;100:109–19.
Article
PubMed
Google Scholar
Pasula MJ. The ALCAT test: in vitro procedure for determining food sensitivities. Folia Med Cracov. 1993;34:153–7.
CAS
PubMed
Google Scholar
Hoffmann-Sommergruber K, Pfeifer S, Bublin M. Applications of molecular diagnostic testing in food allergy. Curr Allergy Asthma Rep. 2015;15:56.
Article
PubMed
PubMed Central
Google Scholar
Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014;133:291–307. quiz 308
Article
CAS
PubMed
Google Scholar
Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126:1105–18.
Article
PubMed
PubMed Central
Google Scholar
Shafer SL, Dexter F. Publication bias, retrospective bias, and reproducibility of significant results in observational studies. Anesth Analg. 2012;114:931–2.
Article
PubMed
Google Scholar
Ali A, Weiss TR, McKee D, Scherban A, Khan S, Fields MR, Apollo D, Mehal WZ. Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial. BMJ Open Gastroenterol. 2017;4:e000164.
Article
PubMed
PubMed Central
Google Scholar
Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology. 2012;143:1158–72.
Article
CAS
PubMed
Google Scholar
Galluzzi L, Bravo-San Pedro JM, Kroemer G. Necrosis: linking the Inflammasome to inflammation. Cell Rep. 2015;11:1501–2.
Article
CAS
PubMed
Google Scholar
Kumagai Y, Takeuchi O, Akira S. TLR9 as a key receptor for the recognition of DNA. Adv Drug Deliv Rev. 2008;60:795–804.
Article
CAS
PubMed
Google Scholar
Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 2009;119:305–14.
CAS
PubMed
PubMed Central
Google Scholar
Hoque R, Farooq A, Malik A, Trawick BN, Berberich DW, McClurg JP, Galen KP, Mehal W. A novel small-molecule enantiomeric analogue of traditional (−)-morphinans has specific TLR9 antagonist properties and reduces sterile inflammation-induced organ damage. J Immunol. 2013;190:4297–304.
Article
CAS
PubMed
PubMed Central
Google Scholar
Garica-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ. Hepatocyte mitochondrial DNA drives non-alcoholic steatohepatitis by activation of TLR9. J Clin Investig. In Press
Dieker J, Schlumberger W, McHugh N, Hamann P, van der Vlag J, Berden JH. Reactivity in ELISA with DNA-loaded nucleosomes in patients with proliferative lupus nephritis. Mol Immunol. 2015;68:20–4.
Article
CAS
PubMed
Google Scholar
Bamboat ZM, Balachandran VP, Ocuin LM, Obaid H, Plitas G, DeMatteo RP. Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury. Hepatology. 2010;51:621–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gschwendt M, Furstenberger G, Leibersperger H, Kittstein W, Lindner D, Rudolph C, Barth H, Kleinschroth J, Marme D, Schachtele C, et al. Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo. Carcinogenesis. 1995;16:107–11.
Article
CAS
PubMed
Google Scholar
Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241–8.
CAS
PubMed
Google Scholar
Garcia-Martinez I, Mehal WZ. DNA: adding injury to insult. Hepatology. 2015;61:35–6.
Article
PubMed
Google Scholar
Leppanen T, Tuominen RK, Moilanen E. Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example. Basic Clin Pharmacol Toxicol. 2014;114:37–43.
Article
PubMed
Google Scholar
Gray RD, Lucas CD, Mackellar A, Li F, Hiersemenzel K, Haslett C, Davidson DJ, Rossi AG. Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps. J Inflamm (Lond). 2013;10:12.
Article
CAS
Google Scholar
Vertegaal AC, Kuiperij HB, Yamaoka S, Courtois G, van der Eb AJ, Zantema A. Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. Cell Signal. 2000;12:759–68.
Article
CAS
PubMed
Google Scholar
Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME, First International Gastrointestinal Eosinophil Research Symposium S. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–63.
Article
CAS
PubMed
Google Scholar
Peterson KA, Byrne KR, Vinson LA, Ying J, Boynton KK, Fang JC, Gleich GJ, Adler DG, Clayton F. Elemental diet induces histologic response in adult eosinophilic esophagitis. Am J Gastroenterol. 2013;108:759–66.
Article
CAS
PubMed
Google Scholar
Ueki S, Konno Y, Takeda M, Moritoki Y, Hirokawa M, Matsuwaki Y, Honda K, Ohta N, Yamamoto S, Takagi Y, et al. Eosinophil extracellular trap cell death-derived DNA traps: their presence in secretions and functional attributes. J Allergy Clin Immunol. 2016;137:258–67.
Article
CAS
PubMed
Google Scholar
Kvarnhammar AM, Cardell LO. Pattern-recognition receptors in human eosinophils. Immunology. 2012;136:11–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Garcia-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ. Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest. 2016;126:859–64.
Article
PubMed
PubMed Central
Google Scholar
Cianferoni A, Spergel J. Eosinophilic esophagitis: a comprehensive review. Clin Rev Allergy Immunol. 2015; https://doi.org/10.1007/s12016-015-8501-z.
Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109:1503–12.
Article
CAS
PubMed
Google Scholar
Lim DM, Wang ML. Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am J Physiol Gastrointest Liver Physiol. 2011;301:G91–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Berin MC, Wang W. Reduced severity of peanut-induced anaphylaxis in TLR9-deficient mice is associated with selective defects in humoral immunity. Mucosal Immunol. 2013;6:114–21.
Article
CAS
PubMed
Google Scholar
Marchesini G, Petta S, Dale Grave R. Diet, weight loss, and liver health in NAFLD: pathophysiology, evidence and practice. Hepatology. 2015; https://doi.org/10.1002/hep.28392.