Evans WJ: What is sarcopenia?. J Gerontol A Biol Sci Med Sci. 1995, 50 Spec No: 5-8.
Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJ: Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005, 19: 422-424.
Durham WJ, Casperson SL, Dillon EL, Keske MA, Paddon-Jones D, Sanford AP, Hickner RC, Grady JJ, Sheffield-Moore M: Age-related anabolic resistance after endurance-type exercise in healthy humans. FASEB J. 2010, 24: 4117-4127. 10.1096/fj.09-150177.
Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR: Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr. 2005, 82: 1065-1073.
Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, Boirie Y: Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004, 18: 1586-1587.
Burd NA, Wall BT, van Loon LJ: The curious case of anabolic resistance: old wives' tales or new fables?. J Appl Physiol. 2012, 112: 1233-1235. 10.1152/japplphysiol.01343.2011.
Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B: The rate of protein digestion affects protein gain differently during aging in humans. J Physiol. 2003, 549: 635-644. 10.1113/jphysiol.2002.036897.
Pennings B, Boirie Y, Senden JM, Gijsen AP, Saris WH, van Loon LJ: Whey protein stimulates postprandial muscle protein accretion more effectively than casein and casein hydrolysate in elderly men. Am J Clin Nutr. 2011, 93: 997-1005. 10.3945/ajcn.110.008102.
Phillips SM, Tang JE, Moore DR: The role of milk- and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. J Am Coll Nutr. 2009, 28: 343-354.
Koopman R, Pannemans DL, Jeukendrup AE, Gijsen AP, Senden JM, Halliday D, Saris WH, van Loon LJ, Wagenmakers AJ: Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise. Am J Physiol Endocrinol Metab. 2004, 287: E712-720. 10.1152/ajpendo.00543.2003.
Fujita S, Glynn EL, Timmerman KL, Rasmussen BB, Volpi E: Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia. 2009, 52: 1889-1898. 10.1007/s00125-009-1430-8.
Fujita S, Rasmussen BB, Cadenas JG, Grady JJ, Volpi E: Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab. 2006, 291: E745-754. 10.1152/ajpendo.00271.2005.
Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR: Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci Sports Exerc. 2003, 35: 449-455. 10.1249/01.MSS.0000053910.63105.45.
Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR: The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab. 2000, 85: 4481-4490. 10.1210/jc.85.12.4481.
Nygren J, Nair KS: Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects. Diabetes. 2003, 52: 1377-1385. 10.2337/diabetes.52.6.1377.
Phillips SM: Insulin and muscle protein turnover in humans: stimulatory, permissive, inhibitory, or all of the above?. Am J Physiol Endocrinol Metab. 2008, 295: E731-10.1152/ajpendo.90569.2008.
Timmerman KL, Volpi E: Amino acid metabolism and regulatory effects in aging. Curr Opin Clin Nutr Metab Care. 2008, 11: 45-49. 10.1097/MCO.0b013e3282f2a592.
Greenhaff PL, Karagounis LG, Peirce N, Simpson EJ, Hazell M, Layfield R, Wackerhage H, Smith K, Atherton P, Selby A, Rennie MJ: Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab. 2008, 295: E595-604. 10.1152/ajpendo.90411.2008.
Meek SE, Persson M, Ford GC, Nair KS: Differential regulation of amino acid exchange and protein dynamics across splanchnic and skeletal muscle beds by insulin in healthy human subjects. Diabetes. 1998, 47: 1824-1835. 10.2337/diabetes.47.12.1824.
Meneilly GS, Elliot T, Bryer-Ash M, Floras JS: Insulin-mediated increase in blood flow is impaired in the elderly. J Clin Endocrinol Metabol. 1995, 80: 1899-1903. 10.1210/jc.80.6.1899.
Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, Clerk LH, Rattigan S: Blood flow and muscle metabolism: a focus on insulin action. Am J Physiol Endocrinol Metab. 2003, 284: E241-258.
Timmerman KL, Lee JL, Dreyer HC, Dhanani S, Glynn EL, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E: Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab. 2010, 95: 3848-3857. 10.1210/jc.2009-2696.
Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E: Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes. 2010, 59: 2764-2771. 10.2337/db10-0415.
Pennings B, Koopman R, Beelen M, Senden JM, Saris WH, van Loon LJ: Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men. Am J Clin Nutr. 2011, 93: 322-331. 10.3945/ajcn.2010.29649.
Pennings B, Groen B, de Lange A, Gijsen AP, Zorenc AH, Senden JM, van Loon LJ: Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab. 2012, 302: E992-999. 10.1152/ajpendo.00517.2011.
Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, Lemosquet S, Saris WH, Boirie Y, van Loon LJ: Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am J Clin Nutr. 2009, 90: 106-115. 10.3945/ajcn.2009.27474.
Smith GI, Atherton P, Villareal DT, Frimel TN, Rankin D, Rennie MJ, Mittendorfer B: Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65–80 year old men and women. PLoS One. 2008, 3: e1875-10.1371/journal.pone.0001875.
Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998, 15: 539-553. 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ: A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care. 2001, 24: 539-548. 10.2337/diacare.24.3.539.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985, 28: 412-419. 10.1007/BF00280883.
Abumrad NN, Rabin D, Diamond MP, Lacy WW: Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism. 1981, 30: 936-940. 10.1016/0026-0495(81)90074-3.
Bergstrom J: Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest. 1975, 35: 609-616. 10.3109/00365517509095787.
van Loon L, Boirie Y, Gijsen A, Fauquant J, de Roos A, Kies A, Lemosquet S, Saris W, Koopman R: The production of intrinsically labeled milk protein provides a functional tool for human nutrition research. J Dairy Sci. 2009, 92: 4812-4822. 10.3168/jds.2009-2317.
Waterval WA, Scheijen JL, Ortmans-Ploemen MM, der Poel CD H-v, Bierau J: Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism. Clin Chim Acta. 2009, 407: 36-42. 10.1016/j.cca.2009.06.023.
Wolfe RR, Chinkes DL: Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis. 2004, Wiley-Liss, [http://www.amazon.com/Isotope-Tracers-Metabolic-Research-Principles/dp/0471462098]
Biolo G, Tessari P, Inchiostro S, Bruttomesso D, Fongher C, Sabadin L, Fratton MG, Valerio A, Tiengo A: Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach. Am J Physiol. 1992, 262: E455-463.
Koopman R, Wagenmakers AJ, Manders RJ, Zorenc AH, Senden JM, Gorselink M, Keizer HA, van Loon LJ: Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab. 2005, 288: E645-653.
Zilversmit DB: The design and analysis of isotope experiments. Am J Med. 1960, 29: 832-848. 10.1016/0002-9343(60)90117-0.
Drummond MJ, Bell JA, Fujita S, Dreyer HC, Glynn EL, Volpi E, Rasmussen BB: Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle. Clin Nutr. 2008, 27: 447-456. 10.1016/j.clnu.2008.01.012.
Koopman R, Beelen M, Stellingwerff T, Pennings B, Saris WH, Kies AK, Kuipers H, van Loon LJ: Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. 2007, 293: E833-842. 10.1152/ajpendo.00135.2007.
Pennings B, Pellikaan W, Senden J, van Vuuren A, Sikkema J, van Loon L: The production of intrinsically labeled milk and meat protein is feasible and provides functional tools for human nutrition research. J Dairy Sci. 2011, 94: 4366-4373. 10.3168/jds.2011-4451.
Fukagawa NK, Minaker KL, Young VR, Rowe JW: Insulin dose-dependent reductions in plasma amino acids in man. Am J Physiol. 1986, 250: E13-17.
Hatzakorzian R, Carvalho G, Bui H, Sato T, Wykes L, Shum-Tim D, Schricker T: High-dose insulin administration is associated with hypoaminoacidemia during cardiac surgery. Metabol: Clin Exp. 2011, 60: 1392-1397. 10.1016/j.metabol.2011.03.007.