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  1. We prospectively examined the association between serum uric acid (SUA) levels and chronic kidney disease (CKD) in China and updated the evidence through a comprehensive meta-analysis of prospective studies wo...

    Authors: Nianwei Wu, Jing Xia, Sen Chen, Chuan Yu, Ying Xu, Chengfu Xu, Tong Yan, Ningxiu Li, Yanjun Liu and Xiong-Fei Pan

    Citation: Nutrition & Metabolism 2021 18:94

    Content type: Research

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  2. In the last few years, the effects of bioactive food components have received much attention because of their beneficial effects including decreasing inflammation, scavenging free radicals, and regulating cell...

    Authors: Nasim Abedimanesh, Somayyeh Asghari, Kosar Mohammadnejad, Zahra Daneshvar, Soudeh Rahmani, Samaneh Shokoohi, Amir Hasan Farzaneh, Seyed Hojjat Hosseini, Iraj Jafari Anarkooli, Maryam Noubarani, Sina Andalib, Mohammad Reza Eskandari and Behrooz Motlagh

    Citation: Nutrition & Metabolism 2021 18:92

    Content type: Research

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  3. Flaxseed is widely used as a functional food for its rich sources of linolenic acid, lignans and dietary fibers in the world. This systematic review and dose–response meta-analysis on randomized controlled tri...

    Authors: Chao Yang, Hui Xia, Min Wan, Yifei Lu, Dengfeng Xu, Xian Yang, Ligang Yang and Guiju Sun

    Citation: Nutrition & Metabolism 2021 18:91

    Content type: Review

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  4. Limited information is available on arterial stiffness risk among hypertensive patients with metabolically abnormal but normal weight. Visceral adiposity index (VAI) is a novel indicator for visceral fat mass ...

    Authors: Junpei Li, Jian Zhu, Ziheng Tan, Yun Yu, Linfei Luo, Wei Zhou, Linjuan Zhu, Tao Wang, Tianyu Cao, Lishun Liu, Huihui Bao, Xiao Huang and Xiaoshu Cheng

    Citation: Nutrition & Metabolism 2021 18:90

    Content type: Research

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  5. Time-restricted feeding is an emerging dietary intervention that is becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted feeding in overweight patients with type ...

    Authors: Tingting Che, Cheng Yan, Dingyuan Tian, Xin Zhang, Xuejun Liu and Zhongming Wu

    Citation: Nutrition & Metabolism 2021 18:88

    Content type: Research

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  6. This study assessed the performance of visceral adiposity index and body shape index in predicting diabetes mellitus (DM) risk and compared their predictive ability to that of body mass index and waist circumf...

    Authors: Meng-Ting Tsou, Yu-Chen Chang, Ching-Ping Hsu, Yang-Che Kuo, Chun-Ho Yun, Wei-Hsin Huang, Kuang-Chun Hu, Chia-Yuan Liu, Ying-Ju Chen, Kuo-Tzu Sung, Chuan-Chuan Liu, Chung-Lieh Hung, Jen-Yuan Kuo, Tung-Ying Chen, Ta-Chuan Hung and Hung-I. Yeh

    Citation: Nutrition & Metabolism 2021 18:87

    Content type: Research

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  7. Precocious puberty is frequently associated with obesity, which will lead to long-term effects, especially on growth and reproduction. However, the effect of precocious puberty on children's neurodevelopment i...

    Authors: Tingbei Bo, Jing Wen, Wenting Gao, Liqiu Tang, Min Liu and Dehua Wang

    Citation: Nutrition & Metabolism 2021 18:86

    Content type: Research

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  8. Androgen receptor (AR) exerts important roles in exercise-induced alterations of muscle mass, in which the proliferation and differentiation of satellite cells or myoblasts are crucial. Our previous study in C...

    Authors: Shaoting Fu, Xiaojing Lin, Lijun Yin and Xiaohui Wang

    Citation: Nutrition & Metabolism 2021 18:85

    Content type: Research

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  9. Increased oxidative/dicarbonyl stress and chronic inflammation are considered key pathophysiological mediators in the progression of complications in obesity and type 2 diabetes (T2D). Lifestyle and diet compo...

    Authors: Hana Malinska, Marta Klementová, Michaela Kudlackova, Jiri Veleba, Eva Hoskova, Olena Oliyarnyk, Irena Markova, Lenka Thieme, Martin Hill, Terezie Pelikanova and Hana Kahleova

    Citation: Nutrition & Metabolism 2021 18:84

    Content type: Research

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  10. Oxidative stress in hepatocytes was important pathogenesis of nonalcoholic steatohepatitis (NASH). Autophagy was a cellular process that can remove damaged organelles under oxidative stress, and thus presented...

    Authors: Li Huang, Xianglong Zeng, Bo Li, Cong Wang, Min Zhou, Hedong Lang, Long Yi and Mantian Mi

    Citation: Nutrition & Metabolism 2021 18:83

    Content type: Research

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  11. As a newly proposed diagnosis, data on the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is rare. We aimed to assess the prevalence and risk factors of MAFLD using new definition i...

    Authors: Jiahua Fan, Shiyun Luo, Yongxin Ye, Jingmeng Ju, Zhuoyu Zhang, Ludi Liu, Jialu Yang and Min Xia

    Citation: Nutrition & Metabolism 2021 18:82

    Content type: Research

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  12. Sanziguben polysaccharides (SZP) are large amounts of classical Chinese medicines from Sanziguben (SZGB). Moreover, SZGB is a widely applied compound prescription for diabetic nephropathy (DN) treatment, but t...

    Authors: Kang Zhou, Jianing Zhang, Chang Liu, Lijuan Ou, Fan Wang, Yang Yu, Yumei Wang and Shasha Bai

    Citation: Nutrition & Metabolism 2021 18:81

    Content type: Research

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  13. This study aimed to examine the effect of yoga training combined with vitamin D supplementation on the expression of survival-related genes in leukocytes and psycho-physical status in breast cancer survivors.

    Authors: Vahid Khedmati Zare, Maedeh Javadi, Sadegh Amani-shalamzari and Mojtaba Kaviani

    Citation: Nutrition & Metabolism 2021 18:80

    Content type: Research

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  14. Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, can lead to morbidity and mortality in both the mother and the infant. Metabolomics has provided new insights into the patho...

    Authors: Wenqian Lu, Mingjuan Luo, Xiangnan Fang, Rong Zhang, Shanshan Li, Mengyang Tang, Xiangtian Yu and Cheng Hu

    Citation: Nutrition & Metabolism 2021 18:79

    Content type: Research

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  15. Hypertension increases the likelihood of cardiovascular diseases (CVDs). Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee dri...

    Authors: Chien-Chou Hou, Disline Manli Tantoh, Chuan-Chao Lin, Pei-Hsin Chen, Hao-Jan Yang and Yung-Po Liaw

    Citation: Nutrition & Metabolism 2021 18:78

    Content type: Research

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  16. Obesity is associated with many comorbidities including inflammatory bowel disease (IBD). We investigated prophylactic effects of an herbal extract (HE) on the DSS-induced colitis mice challenged with high AGE...

    Authors: Fatemeh Azizian-Farsani, Marcin Osuchowski, Navid Abedpoor, Farzad Seyed Forootan, Maryam Derakhshan, Mohammad Hossein Nasr-Esfahani, Mohammad Hasan Sheikhha and Kamran Ghaedi

    Citation: Nutrition & Metabolism 2021 18:77

    Content type: Research

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  17. Data from the 2010–2012 Chinese National Nutrition and Health Survey showed that the vast majority of postmenopausal women in China had dual deficiencies in calcium and estrogen.

    Authors: Hongmei Mao, Wenjun Wang, Lili Shi, Chen Chen, Chao Han, Jinpeng Zhao, Qin Zhuo, Shi Shen, Yan Li and Junsheng Huo

    Citation: Nutrition & Metabolism 2021 18:76

    Content type: Research

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  18. Insulin resistance is associated with prediabetes and further progression to type 2 diabetes mellitus (T2DM). This study aims to investigate novel hepatic lncRNAs associated with key genes in insulin resistanc...

    Authors: Fatemeh Kazeminasab, Sayed Mohammad Marandi, Maryam Baharlooie, Mohammad Hossein Nasr-Esfahani and Kamran Ghaedi

    Citation: Nutrition & Metabolism 2021 18:75

    Content type: Research

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  19. It was evidenced that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to endoplasmic reticulum (ER) calcium release, ER stress, and apoptosis. In the ...

    Authors: Jan Šrámek, Vlasta Němcová and Jan Kovář

    Citation: Nutrition & Metabolism 2021 18:74

    Content type: Brief communication

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  20. Despite the worldwide burden of diverticular disease, the connections between diverticular disease and dietary habits remain poorly understood, particularly in an asymptomatic representative sample. We investi...

    Authors: Esther Askani, Susanne Rospleszcz, Theresa Rothenbacher, Nina Wawro, Helmut Messmann, Carlo N. De Cecco, Ricarda von Krüchten, Charlotte Kulka, Lena S. Kiefer, Wolfgang Rathmann, Annette Peters, Christopher L. Schlett, Fabian Bamberg, Jakob Linseisen and Corinna Storz

    Citation: Nutrition & Metabolism 2021 18:73

    Content type: Research

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  21. Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases. Studies have demonstrated that microRNA-126 (miR-126) was involved in angiogenesis during physiological and pathological proce...

    Authors: Haiyu Li, Xiaoxu Tian, Yongjuan Ruan, Junhui Xing and Zhe Meng

    Citation: Nutrition & Metabolism 2021 18:71

    Content type: Research

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  22. Hypertension is a known risk factor for multiple chronic diseases. Existing literature on the association between frequency of spicy food consumption and hypertension shows mixed findings.

    Authors: Hao Wang, Lingli Chen, Dun Shen, Yuan Cao, Xiaoyi Zhang, Kaixu Xie, Chunmei Wang, Shuiqing Zhu, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen and Liming Li

    Citation: Nutrition & Metabolism 2021 18:70

    Content type: Research

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  23. The incidence of obesity is increasing worldwide, and it is a risk factor for diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Our previous study had demonstrated that high-fat diet induced increa...

    Authors: Hongying Cai, Zhiguo Wen, Kun Meng and Peilong Yang

    Citation: Nutrition & Metabolism 2021 18:69

    Content type: Research

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  24. Metabolic syndrome (MetS) is significantly associated with the risk of cardiovascular disease and its prevalence is showing a trend of getting younger. Previous studies on the relationship between elements and...

    Authors: Huidi Zhang, Qingqing Man, Pengkun Song, Siran Li, Xiaobing Liu, Lijuan Wang, Yuqian Li, Yichun Hu and Lichen Yang

    Citation: Nutrition & Metabolism 2021 18:67

    Content type: Research

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  25. Dairy intake has been implicated in later ovarian aging but mechanism underlying the association is unknown. This study aimed to investigate (1) associations between dairy intake and metabolites previously sho...

    Authors: Nazanin Moslehi, Rezvan Marzbani, Hassan Rezadoost, Parvin Mirmiran, Fahimeh Ramezani Tehrani and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2021 18:66

    Content type: Research

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  26. Impaired hepatic fatty acid metabolism and persistent mitochondrial dysfunction are phenomena commonly associated with liver failure. Decreased serum levels of L-carnitine, a amino acid derivative involved in ...

    Authors: Pengtao Li, Zhengguo Xia, Weichang Kong, Qiong Wang, Ziyue Zhao, Ashley Arnold, Qinglian Xu and Jiegou Xu

    Citation: Nutrition & Metabolism 2021 18:65

    Content type: Research

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  27. This study investigated the mechanisms underlying the preventive effect of dihydromyricetin (DHM) against liver fibrosis involving hepatic stellate cells (HSCs) and hepatic natural killer (NK) cells.

    Authors: Xi Zhou, Li Yu, Min Zhou, Pengfei Hou, Long Yi and Mantian Mi

    Citation: Nutrition & Metabolism 2021 18:64

    Content type: Research

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  28. Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. The associations of hyperuricemia risk with changes in obesity status...

    Authors: Zonglei Zhou, Kunpeng Li, Xianzhi Li, Rongsheng Luan and Ruzhen Zhou

    Citation: Nutrition & Metabolism 2021 18:62

    Content type: Research

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  29. Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested th...

    Authors: Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi and Blake B. Rasmussen

    Citation: Nutrition & Metabolism 2021 18:61

    Content type: Research

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  30. The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes....

    Authors: Catia Martins, Jessica Roekenes, Barbara A. Gower and Gary R. Hunter

    Citation: Nutrition & Metabolism 2021 18:60

    Content type: Research

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  31. To prospectively examine the associations of baseline serum uric acid (SUA) and SUA changes with incident metabolic syndrome (MetS) and update the evidence through a meta-analysis.

    Authors: Sen Chen, Nianwei Wu, Chuan Yu, Ying Xu, Chengfu Xu, Yuli Huang, Jian Zhao, Ningxiu Li and Xiong-Fei Pan

    Citation: Nutrition & Metabolism 2021 18:59

    Content type: Research

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  32. Feeding rhythm disruption contributes to the development of obesity. The receptors of glucagon-like peptide-1 (GLP-1) are distributed in the wide regions of the brain. Among these regions, GLP-1 receptors (GLP...

    Authors: Yuko Maejima, Shoko Yokota, Masaru Shimizu, Shoichiro Horita, Daisuke Kobayashi, Akihiro Hazama and Kenju Shimomura

    Citation: Nutrition & Metabolism 2021 18:58

    Content type: Research

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  33. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation ...

    Authors: Mohammad Alizadeh, Majid Karandish, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei and Reihaneh Mousavi

    Citation: Nutrition & Metabolism 2021 18:57

    Content type: Research

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  34. High-fat diet (HFD)-induced obesity causes immune cells to infiltrate adipose tissue, leading to chronic inflammation and metabolic syndrome. Brown adipose tissue (BAT) can dissipate the energy produced by lip...

    Authors: Pengyu Fu, Rongxin Zhu, Jie Jia, Yang Hu, Chengjun Wu, Pawel Cieszczyk, Hans-Christer Holmberg and Lijing Gong

    Citation: Nutrition & Metabolism 2021 18:56

    Content type: Research

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  35. The TM4 (UBAC2) protein, which contains 4 transmembrane domains and one ubiquitin binding domain, is mainly expressed in cell and nuclear membranes. The current research aimed to explore the role of TM4 in metabo...

    Authors: Lili Chen, Kuanping Ye, Xiaocheng Feng, Lianxi Li, Qin Li, Ying Huang, Xuanchun Wang, Rumei Li, Cheng Hu, Zhen Yang, Bin Lu, Yehong Yang, Jie Wen, Zhaoyun Zhang, Min He, Qinghua Wang…

    Citation: Nutrition & Metabolism 2021 18:54

    Content type: Research

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  36. Soybean oil is a very common edible oil in daily life. With the changes in the dietary composition, the intake of soybean oil increased. However, the effects of dietary intake of soybean oil on testosterone pr...

    Authors: Yu Su, Zhenhua Tian, Xiangyu Qi, Dandan Luo, Luna Liu, Shuang Liu, Dongmei Zheng, Fang Wei, Zhao He and Qingbo Guan

    Citation: Nutrition & Metabolism 2021 18:53

    Content type: Research

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  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Pariyarath Sangeetha Thondre, Helen Lightowler, Lis Ahlstrom and Andrew Gallagher

    Citation: Nutrition & Metabolism 2021 18:52

    Content type: Correction

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    The original article was published in Nutrition & Metabolism 2021 18:41

  38. Whether vitamin D supplementation has any effect on body fat percentage, especially among elite athletes, remains unclear. The aim of this study was to evaluate the effect of vitamin D supplementation on serum...

    Authors: Itaru Kawashima, Takashi Tsukahara, Ryosuke Kawai, Takafumi Mizuno, Shinya Ishizuka, Hideki Hiraiwa and Shiro Imagama

    Citation: Nutrition & Metabolism 2021 18:51

    Content type: Research

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  39. Mitochondrial dysfunction has been implicated as a significant factor in the liver disease process. Blueberry juice and probiotics (BP) synergistically improve liver function in alcoholic fatty liver disease (...

    Authors: Houmin Fan, Yanyan Shen, Ya Ren, Qiuju Mou, Tao Lin, Lili Zhu and Tingting Ren

    Citation: Nutrition & Metabolism 2021 18:50

    Content type: Research

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  40. Tight junction proteins play crucial roles in maintaining the intestinal mucosal barrier. Although previous studies have shown that Notch signaling is closely related to tight junction proteins, the mechanism ...

    Authors: Fubin Qiu, Zehui Zhang, Linxue Yang, Rui Li and Ying Ma

    Citation: Nutrition & Metabolism 2021 18:49

    Content type: Research

    Published on:

  41. Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to...

    Authors: Li Zhang, Ying-juan Huang, Jia-pan Sun, Ting-ying Zhang, Tao-li Liu, Bin Ke, Xian-fang Shi, Hui Li, Geng-peng Zhang, Zhi-yu Ye, Jianguo Hu and Jian Qin

    Citation: Nutrition & Metabolism 2021 18:48

    Content type: Research

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  42. Application of mixed meal tolerance tests (MMTT) to measure beta-cell function in long-term studies is limited by modification of the commercial products occurring over time. This study assessed the intra-indi...

    Authors: Theresa Kössler, Pavel Bobrov, Klaus Strassburger, Oliver Kuss, Oana-Patricia Zaharia, Yanislava Karusheva, Clara Möser, Kálmán Bódis, Volker Burkart, Michael Roden and Julia Szendroedi

    Citation: Nutrition & Metabolism 2021 18:47

    Content type: Brief communication

    Published on:

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