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  1. Content type: Research

    The rise in global obesity makes it crucial to understand how diet drives obesity-related health conditions, such as premature cognitive decline and Alzheimer’s disease (AD). In AD hippocampal-dependent episod...

    Authors: Fiona H. McLean, Fiona M. Campbell, Domenico Sergi, Christine Grant, Amanda C. Morris, Elizabeth A. Hay, Alasdair MacKenzie, Claus D. Mayer, Rosamund F. Langston and Lynda M. Williams

    Citation: Nutrition & Metabolism 2019 16:57

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  2. Content type: Brief communication

    We previously demonstrated that improved net muscle protein balance, via enhanced protein synthetic efficiency, occurs 5 days after testosterone (T) administration. Whether the effects of T on muscle protein k...

    Authors: David D. Church, Stefan M. Pasiakos, Robert R. Wolfe and Arny A. Ferrando

    Citation: Nutrition & Metabolism 2019 16:56

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  3. Content type: Research

    Iron nutrition is important for the health of women of reproductive age, and defining the physiologic requirement for iron can help them accurately plan the iron intake. However, research on the physiologic re...

    Authors: Jiaxi Lu, Jie Cai, Tongxiang Ren, Jinghuan Wu, Deqian Mao, Weidong Li, Yu Zhang, Jianhua Piao, Jun Wang, Lichen Yang, Xiaoguang Yang and Yuxia Ma

    Citation: Nutrition & Metabolism 2019 16:55

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  4. Content type: Research

    The prevalence of obesity and excessive gestational weight gain (GWG) has been increasing worldwide. The aims of this study were to evaluate associations of prepregnancy body mass index (BMI) and rate of GWG i...

    Authors: Xueyin Wang, Xiaosong Zhang, Min Zhou, Juan Juan and Xu Wang

    Citation: Nutrition & Metabolism 2019 16:54

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  5. Content type: Research

    Currently available treatments for colorectal cancer (CRC) associate with numerous side-effects that reduce patients’ quality of life. The effective nutraceuticals with high anti-proliferative efficacy and low...

    Authors: Abilasha Gayani Jayathilake, Elif Kadife, Rodney Brain Luwor, Kulmira Nurgali and Xiao Qun Su

    Citation: Nutrition & Metabolism 2019 16:53

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  6. Content type: Research

    The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid...

    Authors: Shilong Xiang, Xiaohui Zhang, Xishao Xie, Junni Wang, Qin Zhou, Zhimin Chen, Yaomin Wang, Guangjun Liu, Fei Han and Jianghua Chen

    Citation: Nutrition & Metabolism 2019 16:52

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  7. Content type: Research

    Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfuncti...

    Authors: Irena Markova, Martina Hüttl, Olena Oliyarnyk, Tereza Kacerova, Martin Haluzik, Petr Kacer, Ondrej Seda and Hana Malinska

    Citation: Nutrition & Metabolism 2019 16:51

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  8. Content type: Research

    Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lip...

    Authors: Yunxia Zhu, Xiaoyan Zhang, Li Zhang, Mingliang Zhang, Ling Li, Deng Luo and Yuan Zhong

    Citation: Nutrition & Metabolism 2019 16:50

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  9. Content type: Research

    Plant-based food medicine and functional foods have been consumed extensively due to their bioactive substances and health-beneficial effects. Vinegar is one of them due to its bioactivities, which confers ben...

    Authors: Nurul Elyani Mohamad, Nadiah Abu, Swee Keong Yeap, Kian Lam Lim, Muhammad Firdaus Romli, Shaiful Adzni Sharifuddin, Kamariah Long and Noorjahan Banu Alitheen

    Citation: Nutrition & Metabolism 2019 16:49

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  10. Content type: Research

    Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction sig...

    Authors: Yoo Kim, Michael Rouse, Isabel González-Mariscal, Josephine M. Egan and Jennifer F. O’Connell

    Citation: Nutrition & Metabolism 2019 16:48

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  11. Content type: Review

    Flavonoids are a class of plant and fungus secondary metabolites and are the most common group of polyphenolic compounds in the human diet. In recent studies, flavonoids have been shown to induce browning of w...

    Authors: Xuejun Zhang, Xin Li, Huang Fang, Fengjin Guo, Feng Li, Anmin Chen and Shilong Huang

    Citation: Nutrition & Metabolism 2019 16:47

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  12. Content type: Research

    There is a growing interest in the pathopysiological consequences of postprandial hyperglycemia. It is well known that in diabetic patients 2 h plasma glucose is a better risk predictor for coronary heart dise...

    Authors: María González-Rodríguez, Marcos Pazos-Couselo, José M. García-López, Santiago Rodríguez-Segade, Javier Rodríguez-García, Carmen Túñez-Bastida and Francisco Gude

    Citation: Nutrition & Metabolism 2019 16:46

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  13. Content type: Research

    Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new...

    Authors: Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi and Shimpei Ushio

    Citation: Nutrition & Metabolism 2019 16:45

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  14. Content type: Research

    Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between viscer...

    Authors: Xiaohui Guo, Yifan Xu, Hairong He, Hao Cai, Jianfen Zhang, Yibin Li, Xinyu Yan, Man Zhang, Na Zhang, Rolando L. Maddela and Guansheng Ma

    Citation: Nutrition & Metabolism 2019 16:44

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  15. Content type: Research

    The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resist...

    Authors: Tomomi Sano, Taiki Sanada, Yusuke Sotomaru, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Takashi Kanematsu and Fusanori Nishimura

    Citation: Nutrition & Metabolism 2019 16:43

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  16. Content type: Research

    Endothelial oxidative injury is a key event in the pathogenesis of atherosclerosis (AS). Resveratrol (RSV) attenuates the oxidative injury in human umbilical vein endothelial cells (HUVECs). Autophagy is criti...

    Authors: Xi Zhou, Jining Yang, Min Zhou, Yu Zhang, Yang Liu, Pengfei Hou, Xianglong Zeng, Long Yi and Mantian Mi

    Citation: Nutrition & Metabolism 2019 16:42

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  17. Content type: Research

    Apolipoprotein A-IV (ApoA-IV) exists in relatively high levels in the circulation systems of animals, but its roles are not fully elucidated. It is known that the Apoa4 gene resides in the cluster Apoa1/Apoc3/Apo...

    Authors: Zhenguo Wang, Lu Wang, Zhuzhen Zhang, Li Feng, Xue Song and Jiarui Wu

    Citation: Nutrition & Metabolism 2019 16:41

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  18. Content type: Research

    As reported previously by our group, medium-chain triglycerides can ameliorate atherosclerosis. Given that TLR4 is closely related to atherosclerosis, we hypothesized herein that caprylic acid (C8:0) would sup...

    Authors: Xinsheng Zhang, Changyong Xue, Qing Xu, Yong Zhang, Huizi Li, Feng Li, Yinghua Liu and Changjiang Guo

    Citation: Nutrition & Metabolism 2019 16:40

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  19. Content type: Research

    Long non-coding RNAs (lncRNAs) are involved in numerous physiological functions. Yet, their mechanisms in coronary artery disease (CAD) are not well understood.

    Authors: Liu Miao, Rui-Xing Yin, Qing-Hui Zhang, Xi-Jiang Hu, Feng Huang, Wu-Xian Chen, Xiao-Li Cao and Jin-Zhen Wu

    Citation: Nutrition & Metabolism 2019 16:39

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  20. Content type: Research

    The incidence of metabolic syndrome linked to dyslipidemia and insulin resistance has increased; thus, studies must be conducted to elucidate this phenomenon. The present study aimed to investigate the protect...

    Authors: Oeuk Jeong and Hyun-Sook Kim

    Citation: Nutrition & Metabolism 2019 16:38

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  21. Content type: Research

    Proliferative diabetic retinopathy (PDR), a sight-threatening retinopathy, is the leading cause of irreversible blindness in adults. Despite strict control of systemic risk factors, a fraction of patients with...

    Authors: Xiao-Rong Zhu, Fang-yuan Yang, Jing Lu, Hui-rong Zhang, Ran Sun, Jian-Bo Zhou and Jin-Kui Yang

    Citation: Nutrition & Metabolism 2019 16:37

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  22. Content type: Research

    High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development...

    Authors: Kuen-Ming Wu, Yuan-Man Hsu, Mei-Chin Ying, Fuu-Jen Tsai, Chang-Hai Tsai, Jing-Gung Chung, Jai-Sing Yang, Chih-Hsin Tang, Li-Yi Cheng, Po-Hua Su, Vijaya Padma Viswanadha, Wei-Wen Kuo and Chih-Yang Huang

    Citation: Nutrition & Metabolism 2019 16:36

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  23. Content type: Research

    Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to det...

    Authors: Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang and Xiaoqing Tang

    Citation: Nutrition & Metabolism 2019 16:34

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  24. Content type: Review

    Cutaneous malignant melanoma is a heterogeneous disease, being the consequence of specific genetic alterations along several molecular pathways. Despite the increased knowledge about the biology and pathogenes...

    Authors: Maria Neve Ombra, Panagiotis Paliogiannis, Luigia Stefania Stucci, Maria Colombino, Milena Casula, Maria Cristina Sini, Antonella Manca, Grazia Palomba, Ignazio Stanganelli, Mario Mandalà, Sara Gandini, Amelia Lissia, Valentina Doneddu, Antonio Cossu and Giuseppe Palmieri

    Citation: Nutrition & Metabolism 2019 16:33

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  25. Content type: Research

    Adipogenesis, the process of preadipocyte differentiation to mature adipocytes accompanied by accumulation of intracytoplasmic lipid droplets, is regulated by various genetic and environmental factors, and clo...

    Authors: Yusuke Ando, Fumiaki Sato, Hazuki Fukunaga, Yusuke Iwasaki, Yoshihiko Chiba, Masahiko Tebakari, Yuki Daigo, Junichi Kawashima and Junzo Kamei

    Citation: Nutrition & Metabolism 2019 16:32

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  26. Content type: Research

    Obesity increases the risk of metabolic dysfunction such as dyslipidemia, hypertension, and fatty liver. Physcion (PY) is an anthraquinone that reportedly has anti-inflammatory and anti-bacterial properties. H...

    Authors: Seon-Jeong Lee, Su-Jung Cho, Eun-Young Kwon and Myung-Sook Choi

    Citation: Nutrition & Metabolism 2019 16:31

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  27. Content type: Research

    Several biomarkers are used to measure iron deficiency (ID) during pregnancy, but the prevalence of ID and its association with adverse birth outcomes shows inconsistent results. The aim of this study was to e...

    Authors: Xiaosong Yuan, Huiwen Hu, Ming Zhang, Wei Long, Jianbing Liu, Jian Jiang and Bin Yu

    Citation: Nutrition & Metabolism 2019 16:30

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  28. Content type: Research

    It is not clear whether the frequently reported phenomenon of exercise-induced anorexia is exacerbated or blunted in warm or cold environments. Therefore, this study investigated the effects of exercise in thr...

    Authors: Iva Mandic, Mavra Ahmed, Shawn Rhind, Len Goodman, Mary L’Abbe and Ira Jacobs

    Citation: Nutrition & Metabolism 2019 16:29

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  29. Content type: Research

    This study aimed to assess the potential effects of long-term intake of caffeine and habitual consumption of coffee and tea on the occurrence of cardio-renal events among an Iranian population with low coffee ...

    Authors: Zahra Gaeini, Zahra Bahadoran, Parvin Mirmiran and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2019 16:28

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  30. Content type: Research

    Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type...

    Authors: Luting Wu, Li Ran, Hedong Lang, Min Zhou, Li Yu, Long Yi, Jundong Zhu, Lei Liu and Mantian Mi

    Citation: Nutrition & Metabolism 2019 16:27

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  31. Content type: Research

    Prolonged over-consumption of a high-fat diet (HFD) commonly leads to obesity and insulin resistance. However, even 3 days of HFD consumption has been linked to inflammation within the key homeostatic brain re...

    Authors: Fiona H. McLean, Fiona M. Campbell, Rosamund F. Langston, Domenico Sergi, Cibell Resch, Christine Grant, Amanda C. Morris, Claus D. Mayer and Lynda M. Williams

    Citation: Nutrition & Metabolism 2019 16:26

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  32. Content type: Research

    Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood. In this study, we examin...

    Authors: Zhe Meng, Mengyu Wang, Junhui Xing, Yuzhou Liu and Haiyu Li

    Citation: Nutrition & Metabolism 2019 16:25

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  33. Content type: Research

    Consumption of diet high in soy products is suggested to contribute to lower prostate cancer incidence in Asian men. But little has been known about the influences of dietary patterns on gut microbiota and mic...

    Authors: Yufei Liu, Xiaobo Wu and Haowen Jiang

    Citation: Nutrition & Metabolism 2019 16:24

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  34. Content type: Research

    The process of atherosclerosis begins early in childhood and usually remains asymptomatic until later in life. Carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis could identify ea...

    Authors: Maryam Aghayan, Golaleh Asghari, Emad Yuzbashian, Pooneh Dehghan, Hossein Khadem Haghighian, Parvin Mirmiran and Maryam Javadi

    Citation: Nutrition & Metabolism 2019 16:23

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  35. Content type: Research

    Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in obesity-related diseases such as type 2 diabetes. The effects of SIRT1 on integration of metabolism and inflammation may p...

    Authors: Hung-Wen Liu, Hao-Han Kao and Chi-Hang Wu

    Citation: Nutrition & Metabolism 2019 16:22

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  36. Content type: Research

    Differences in total body and regional adiposity according to sex are observed from an early age, but these differences become more evident after puberty due to hormonal changes. We aimed to assess the evoluti...

    Authors: Silvana Paiva Orlandi, Leonardo Pozza Santos, Ana Maria Baptista Menezes, Fernando C. Wehrmeister, Helen Gonçalves and Maria Cecília Formoso Assunção

    Citation: Nutrition & Metabolism 2019 16:21

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  37. Content type: Research

    Maternal undernutrition programs fetal energy homeostasis and increases the risk of metabolic disorders later in life. This study aimed to identify the signs of hepatic metabolic programming in utero and durin...

    Authors: Xiaoling Zhou, Hong Yang, Qiongxian Yan, Ao Ren, Zhiwei Kong, Shaoxun Tang, Xuefeng Han, Zhiliang Tan and Abdelfattah Z. M. Salem

    Citation: Nutrition & Metabolism 2019 16:20

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  38. Content type: Research

    Maternal riboflavin deficiency (RD) induces embryonic death in poultry. The underlying mechanisms, however, remain to be established and an overview of molecular alterations at the protein level is still lacki...

    Authors: Jing Tang, Jian Hu, Ming Xue, Zhanbao Guo, Ming Xie, Bo Zhang, Zhengkui Zhou, Wei Huang and Shuisheng Hou

    Citation: Nutrition & Metabolism 2019 16:19

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  39. Content type: Research

    Gut derived toxins such as p-cresol, p-cresyl sulfate (pCS) and indoxyl sulfate (IS), which belong to protein-bound uremic toxins that promote development of fibrosis inflammatory state associated with chronic...

    Authors: Hamid Tayebi Khosroshahi, Behzad Abedi, Morteza Ghojazadeh, Azam Samadi and Abolghasem Jouyban

    Citation: Nutrition & Metabolism 2019 16:18

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  40. Content type: Research

    To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism ...

    Authors: Xiaojing Lin, Yanan Yang, Jing Qu and Xiaohui Wang

    Citation: Nutrition & Metabolism 2019 16:17

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  41. Content type: Research

    Epidemiological and experimental studies have extensively indicated that chronic subclinical systemic inflammation (CSSI) and oxidative stress are risk factors for several chronic diseases, including cancer, a...

    Authors: Yazan Ranneh, Abdah Md Akim, Hasiah Ab Hamid, Huzwah Khazaai, Abdulmannan Fadel and Ayman M. Mahmoud

    Citation: Nutrition & Metabolism 2019 16:15

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  42. Content type: Research

    Adiponectin exerts several beneficial cardiovascular effects, however their specific molecular mechanisms require additional understanding. This study investigated the mechanisms of adiponectin action in the h...

    Authors: Amy Botta, Ying Liu, Sivaporn Wannaiampikul, Rungsunn Tungtrongchitr, Keith Dadson, Tae-Sik Park and Gary Sweeney

    Citation: Nutrition & Metabolism 2019 16:14

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  43. Content type: Research

    Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between ...

    Authors: Mario A. Miranda, Celine L. St Pierre, Juan F. Macias-Velasco, Huyen Anh Nguyen, Heather Schmidt, Lucian T. Agnello, Jessica P. Wayhart and Heather A. Lawson

    Citation: Nutrition & Metabolism 2019 16:13

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  44. Content type: Research

    Oil tea is a type of traditional tea beverage used for treating various ailments in minority population in Guangxi, China. Our previous study showed oil tea improved glucose and lipid levels in type 2 diabetic...

    Authors: Qiantu Hu, Huafeng Chen, Yanli Zuo, Qin He, Xuan He, Steve Simpson Jr, Wei Huang, Hui Yang, Haiying Zhang and Rui Lin

    Citation: Nutrition & Metabolism 2019 16:12

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  45. Content type: Research

    Catch-up growth in adult (CUGA) is characterized by visceral fat accumulation, ectopic lipid deposition and insulin resistance (IR). Here, we investigated the determinants of these pathophysiological consequen...

    Authors: Yan Li, Shan Yu, Lulu Chen, Xiang Hu, Juan Zheng and Xiuling Deng

    Citation: Nutrition & Metabolism 2019 16:11

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  46. Content type: Research

    Oxidative stress-induced damage in endothelial cells is a crucial initiator of atherosclerosis (AS), which is highly related to excessive reactive oxygen species (ROS) and mitochondrial dynamics. Resveratrol (...

    Authors: Jining Yang, Xi Zhou, Xianglong Zeng, Ou Hu, Long Yi and Mantian Mi

    Citation: Nutrition & Metabolism 2019 16:9

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  47. Content type: Research

    Since lifestyle changes are main therapies for non-alcoholic fatty liver disease (NAFLD), changing dietary components (nutritional or bioactive) may play a parallel important role. Few studies have assessed th...

    Authors: Seyed Ali Jazayeri-Tehrani, Seyed Mahdi Rezayat, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Milad Daneshi-Maskooni and Mohammad-Javad Hosseinzadeh-Attar

    Citation: Nutrition & Metabolism 2019 16:8

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