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  1. Research

    Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats

    Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat ...

    Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy and Satthi Babu VVU

    Nutrition & Metabolism 2017 14:72

    Published on: 16 November 2017

  2. Research

    An excess dietary vitamin E concentration does not influence Nrf2 signaling in the liver of rats fed either soybean oil or salmon oil

    Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body. Th...

    Klaus Eder, Marina Siebers, Erika Most, Susan Scheibe, Norbert Weissmann and Denise K. Gessner

    Nutrition & Metabolism 2017 14:71

    Published on: 16 November 2017

  3. Research

    Total energy expenditure of 10- to 12-year-old Japanese children measured using the doubly labeled water method

    To establish Japanese children’s estimated energy requirements, total energy expenditure (TEE) data measured using the doubly labeled water (DLW) method is needed. This study aimed to 1) obtain basic TEE data ...

    Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura and Kojiro Ishii

    Nutrition & Metabolism 2017 14:70

    Published on: 15 November 2017

  4. Research

    Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?

    NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations....

    Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski and Karolina Konstantynowicz-Nowicka

    Nutrition & Metabolism 2017 14:69

    Published on: 13 November 2017

  5. Research

    Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

    This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2).

    Yan-Hong Huang, Ting-Ting Ye, Chong-Xiao Liu, Lei Wang, Yuan-Wen Chen and Yan Dong

    Nutrition & Metabolism 2017 14:67

    Published on: 2 November 2017

  6. Research

    Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

    High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal muc...

    Octave Mucunguzi, Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, André Boivin, Ezequiel-Luis Calvo and Jonny St-Amand

    Nutrition & Metabolism 2017 14:66

    Published on: 23 October 2017

  7. Research

    Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat

    Toll-like receptor 4 (TLR4), an innate immune receptor, is suspected to play a key role in the postprandial inflammation that is induced by a high-fat meal rich in saturated fatty acids (SFA). Our objective wa...

    Dominique Hermier, Véronique Mathé, Annaïg Lan, Clélia Santini, Annie Quignard-Boulangé, Jean-François Huneau and François Mariotti

    Nutrition & Metabolism 2017 14:65

    Published on: 19 October 2017

  8. Research

    Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

    The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio an...

    Li Zhao, Jing Cheng, Yingchao Chen, Qin Li, Bing Han, Yi Chen, Fangzhen Xia, Chi Chen, Dongping Lin, Xuemei Yu, Ningjian Wang and Yingli Lu

    Nutrition & Metabolism 2017 14:64

    Published on: 10 October 2017

  9. Research

    Markers of neuroprotection of combined EPA and DHA provided by fish oil are higher than those of EPA (Nannochloropsis) and DHA (Schizochytrium) from microalgae oils in Wistar rats

    To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosa...

    Paula A. Lopes, Narcisa M. Bandarra, Susana V. Martins, Joana Martinho, Cristina M. Alfaia, Marta S. Madeira, Carlos Cardoso, Cláudia Afonso, Maria C. Paulo, Rui M. A. Pinto, José L. Guil-Guerrero and José A. M. Prates

    Nutrition & Metabolism 2017 14:62

    Published on: 29 September 2017

  10. Reaearch

    Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial

    Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid...

    Arrigo F.G. Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D’Addato and Claudio Borghi

    Nutrition & Metabolism 2017 14:61

    Published on: 25 September 2017

  11. Research

    Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

    Previously, we reported that a low-protein diet significantly reduced insulin secretion in response to feeding within 1 h in rats, suggesting that the insulinotropic effect of dietary protein plays an importan...

    Mami Horiuchi, Tomoya Takeda, Hiroyuki Takanashi, Yori Ozaki-Masuzawa, Yusuke Taguchi, Yuka Toyoshima, Lila Otani, Hisanori Kato, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka

    Nutrition & Metabolism 2017 14:59

    Published on: 15 September 2017

  12. Research

    Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial

    Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in m...

    Christopher Papandreou, Mònica Bullò, Francisco José Tinahones, Miguel Ángel Martínez-González, Dolores Corella, Georgios A. Fragkiadakis, José López-Miranda, Ramon Estruch, Montserrat Fitó and Jordi Salas-Salvadó

    Nutrition & Metabolism 2017 14:58

    Published on: 2 September 2017

  13. Research

    Phenylketonuria patients’ and their parents’ knowledge and attitudes to the daily diet - multi-centre study

    The aim of the study was to assess both patients’ and their parents’ knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet.

    Ewa Witalis, Bozena Mikoluc, Radoslaw Motkowski, Jolanta Sawicka-Powierza, Agnieszka Chrobot, Bozena Didycz, Agata Lange, Renata Mozrzymas, Andrzej Milanowski, Maria Nowacka, Mariola Piotrowska-Depta, Hanna Romanowska, Ewa Starostecka, Jolanta Wierzba, Magdalena Skorniewska, Barbara Iwona Wojcicka-Bartlomiejczyk…

    Nutrition & Metabolism 2017 14:57

    Published on: 17 August 2017

  14. Research

    Recombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis

    Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatit...

    Lili Chen, Xiaolong Zhao, Guangjun Liang, Jiuru Sun, Zhifeng Lin, Renming Hu, Peili Chen, Zhaoyun Zhang, Linuo Zhou and Yiming Li

    Nutrition & Metabolism 2017 14:56

    Published on: 15 August 2017

  15. Research

    Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin

    Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigat...

    Lu Lei, Kejia Li, Ling Li, Xia Fang, Tingting Zhou, Cheng Zhang, Yong Luo, Hua Liu, Xiaoqiang Li, Hongting Zheng, Lin Zhang, Gangyi Yang and Lin Gao

    Nutrition & Metabolism 2017 14:53

    Published on: 14 August 2017

  16. Research

    Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity

    Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingest...

    Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu and Guiju Sun

    Nutrition & Metabolism 2017 14:54

    Published on: 14 August 2017

  17. Research

    DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes

    Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were rep...

    Jia Song, Cheng Li, Yushan Lv, Yi Zhang, William Kwame Amakye and Limei Mao

    Nutrition & Metabolism 2017 14:52

    Published on: 11 August 2017

  18. Research

    Season and vitamin D status are independently associated with glucose homeostasis in pregnancy

    Vitamin D status and season are intrinsically linked, and both have been proposed to be associated with glucose homeostasis in pregnancy, with conflicting results. We aimed to determine if exposure to winter a...

    Eileen C. O’Brien, Elizabeth J. O’Sullivan, Mark T. Kilbane, Aisling A. Geraghty, Malachi J. McKenna and Fionnuala M. McAuliffe

    Nutrition & Metabolism 2017 14:50

    Published on: 2 August 2017

  19. Research

    Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: a randomized, crossover, controlled feeding trial

    Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared...

    Chiao-Ming Chen, Jen-Fang Liu, Sing-Chung Li, Chen-Ling Huang, An-Tsz Hsirh, Shuen-Fu Weng, Mei-Ling Chang, Hung-Ta Li, Emily Mohn and C-Y. Oliver Chen

    Nutrition & Metabolism 2017 14:51

    Published on: 2 August 2017

  20. Research

    eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

    Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse ce...

    Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman and Sung Hoon Back

    Nutrition & Metabolism 2017 14:48

    Published on: 1 August 2017

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