Vettor R, Pagotto U, Pagano C, Pasquali R: Here, there and everywhere: the endocannabinoid system. JNeuroendocrinol. 2008, 20 (Suppl 1): iv-vi.
Article
Google Scholar
Bisogno T: Endogenous cannabinoids: structure and metabolism. JNeuroendocrinol. 2008, 20 (Suppl 1): 1-9.
Article
Google Scholar
Mackie K: Cannabinoid receptors: where they are and what they do. JNeuroendocrinol. 2008, 20 (Suppl 1): 10-14.
Article
Google Scholar
Cota D, Marsicano G, Lutz B, Vicennati V, Stalla GK, Pasquali R, Pagotto U: Endogenous cannabinoid system as a modulator of food intake. IntJObesRelat Metab Disord. 2003, 27: 289-301.
Article
Google Scholar
Cota D, Marsicano G, Tschop M, Grubler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thone-Reineke C, Ortmann S: The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. JClinInvest. 2003, 112: 423-431.
Google Scholar
Bellocchio L, Cervino C, Vicennati V, Pasquali R, Pagotto U: Cannabinoid type 1 receptor: another arrow in the adipocytes' bow. JNeuroendocrinol. 2008, 20 (Suppl 1): 130-138.
Article
Google Scholar
Bensaid M, Gary-Bobo M, Esclangon A, Maffrand JP, Le FG, Oury-Donat F, Soubrie P: The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. MolPharmacol. 2003, 63: 908-914.
Google Scholar
Engeli S, Bohnke J, Feldpausch M, Gorzelniak K, Janke J, Batkai S, Pacher P, Harvey-White J, Luft FC, Sharma AM, Jordan J: Activation of the peripheral endocannabinoid system in human obesity. Diabetes. 2005, 54: 2838-2843. 10.2337/diabetes.54.10.2838.
Article
Google Scholar
Bouaboula M, Hilairet S, Marchand J, Fajas L, Le FG, Casellas P: Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. EurJPharmacol. 2005, 517: 174-181.
Google Scholar
Gasperi V, Fezza F, Pasquariello N, Bari M, Oddi S, Agro AF, Maccarrone M: Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. Cell MolLife Sci. 2007, 64: 219-229.
Article
Google Scholar
Matias I, Gonthier MP, Orlando P, Martiadis V, De PL, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R: Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. JClinEndocrinolMetab. 2006, 91: 3171-3180.
Google Scholar
Pagano C, Pilon C, Calcagno A, Urbanet R, Rossato M, Milan G, Bianchi K, Rizzuto R, Bernante P, Federspil G, Vettor R: The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms. J Clin Endocrinol Metab. 2007, 92: 4810-4819. 10.1210/jc.2007-0768.
Article
Google Scholar
Pagano C, Rossato M, Vettor R: Endocannabinoids, adipose tissue and lipid metabolism. JNeuroendocrinol. 2008, 20 (Suppl 1): 124-129.
Article
Google Scholar
Bluher M, Engeli S, Kloting N, Berndt J, Fasshauer M, Batkai S, Pacher P, Schon MR, Jordan J, Stumvoll M: Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. 2006, 55: 3053-3060. 10.2337/db06-0812.
Article
Google Scholar
D'Eon TM, Pierce KA, Roix JJ, Tyler A, Chen H, Teixeira SR: The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids. Diabetes. 2008, 57: 1262-1268. 10.2337/db07-1186.
Article
Google Scholar
Ravinet TC, Delgorge C, Menet C, Arnone M, Soubrie P: CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. IntJObesRelat Metab Disord. 2004, 28: 640-648.
Article
Google Scholar
Pellizzon M, Buison A, Ordiz F, Santa AL, Jen KL: Effects of dietary fatty acids and exercise on body-weight regulation and metabolism in rats. ObesRes. 2002, 10: 947-955.
Google Scholar
Matias I, Carta G, Murru E, Petrosino S, Banni S, Di MV: Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes. BiochimBiophysActa. 2008, 1781: 52-60.
Google Scholar
Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschop J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z: Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes. 2008, 57: 2977-2991. 10.2337/db08-0161.
Article
Google Scholar
Tam J, Vemuri VK, Liu J, Batkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J: Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest. 2010, 120: 2953-2966. 10.1172/JCI42551.
Article
Google Scholar
Koolman AH, Bloks VW, Oosterveer MH, Jonas I, Kuipers F, Sauer PJ, van Dijk G: Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition. Int J Obes (Lond). 2010, 34: 374-384. 10.1038/ijo.2009.219.
Article
Google Scholar
Riachi M, Himms-Hagen J, Harper ME: Percent relative cumulative frequency analysis in indirect calorimetry: application to studies of transgenic mice. Can J Physiol Pharmacol. 2004, 82: 1075-1083. 10.1139/y04-117.
Article
Google Scholar
Liu MY, Xydakis AM, Hoogeveen RC, Jones PH, Smith EO, Nelson KW, Ballantyne CM: Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system. Clin Chem. 2005, 51: 1102-1109. 10.1373/clinchem.2004.047084.
Article
Google Scholar
Chwalibog A, Jakobsen K, Tauson AH, Thorbek G: Heat production and substrate oxidation in rats fed at maintenance level and during fasting. Comp Biochem Physiol A Mol Integr Physiol. 1998, 121: 423-429. 10.1016/S1095-6433(98)10153-8.
Article
Google Scholar
Jequier E, Acheson K, Schutz Y: Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr. 1987, 7: 187-208. 10.1146/annurev.nu.07.070187.001155.
Article
Google Scholar
Lusk G: The elements of the science of nutrition. 1924, New York: Johnson Reprint Corp, 4
Google Scholar
Wiegman CH, Bandsma RH, Ouwens M, van der Sluijs FH, Havinga R, Boer T, Reijngoud DJ, Romijn JA, Kuipers F: Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes. 2003, 52: 1081-1089. 10.2337/diabetes.52.5.1081.
Article
Google Scholar
Oosterveer MH, Van Dijk TH, Tietge UJF, Boer T, Havinga R, Stellaard F, Groen AK, Kuipers F, Reijngoud DJ: High fat feeding induces hepatic fatty acid elongation in mice. PLoSOne. 2009, 4: e6066-
Article
Google Scholar
Lee WN, Byerley LO, Bergner EA, Edmond J: Mass isotopomer analysis: theoretical and practical considerations. BiolMass Spectrom. 1991, 20: 451-458.
Article
Google Scholar
Laplante M, Sell H, MacNaul KL, Richard D, Berger JP, Deshaies Y: PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Diabetes. 2003, 52: 291-299.
Article
Google Scholar
Li ZZ, Berk M, McIntyre TM, Feldstein AE: Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. JBiolChem. 2009, 284: 5637-5644.
Google Scholar
Lichtenstein L, Kersten S: Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1. Biochimica et biophysica acta. 2010, 1801: 415-420.
Article
Google Scholar
Voshol PJ, Rensen PC, van Dijk KW, Romijn JA, Havekes LM: Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models. Biochimica et biophysica acta. 2009, 1791: 479-485.
Article
Google Scholar
Constant VA, Gagnon A, Landry A, Sorisky A: Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes. Diabetologia. 2006, 49: 1402-1411. 10.1007/s00125-006-0253-0.
Article
Google Scholar
Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Batkai S, Harvey-White J, Mackie K, Offertaler L, Wang L, Kunos G: Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. JClinInvest. 2005, 115: 1298-1305.
Google Scholar
van Schothorst EM, Flachs P, Franssen-van Hal NL, Kuda O, Bunschoten A, Molthoff J, Vink C, Hooiveld GJ, Kopecky J, Keijer J: Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet. BMCGenomics. 2009, 10: 110-
Google Scholar
Choi KC, Ryu OH, Lee KW, Kim HY, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH, Choi KM: Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats. BiochemBiophysResCommun. 2005, 336: 747-753.
Google Scholar
Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J: C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005, 54: 1744-1754. 10.2337/diabetes.54.6.1744.
Article
Google Scholar
Bullen JW, Bluher S, Kelesidis T, Mantzoros CS: Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. American journal of physiology Endocrinology and metabolism. 2007, 292: E1079-1086.
Article
Google Scholar
Lofgren P, Sjolin E, Wahlen K, Hoffstedt J: Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level. J Clin Endocrinol Metab. 2007, 92: 1555-1559. 10.1210/jc.2006-2240.
Article
Google Scholar
Liu YL, Connoley IP, Wilson CA, Stock MJ: Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. IntJObes(Lond). 2005, 29: 183-187.
Google Scholar
Bederman IR, Foy S, Chandramouli V, Alexander JC, Previs SF: Triglyceride synthesis in epididymal adipose tissue: contribution of glucose and non-glucose carbon sources. JBiolChem. 2009, 284: 6101-6108.
Google Scholar
Ruby MA, Nomura DK, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM: Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. ProcNatlAcadSciUSA. 2008, 105: 14561-14566.
Article
Google Scholar
Molhoj S, Hansen HS, Schweiger M, Zimmermann R, Johansen T, Malmlof K: Effect of the cannabinoid receptor-1 antagonist rimonabant on lipolysis in rats. Eur J Pharmacol. 2010, 646: 38-45. 10.1016/j.ejphar.2010.08.006.
Article
Google Scholar
Flamment M, Gueguen N, Wetterwald C, Simard G, Malthiery Y, Ducluzeau PH: Effects of the cannabinoid CB1 antagonist, rimonabant, on hepatic mitochondrial function in rats fed a high fat diet. Am J Physiol Endocrinol Metab. 2009
Google Scholar
Perwitz N, Wenzel J, Wagner I, Buning J, Drenckhan M, Zarse K, Ristow M, Lilienthal W, Lehnert H, Klein J: Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes. Diabetes Obes Metab. 2010, 12: 158-166. 10.1111/j.1463-1326.2009.01133.x.
Article
Google Scholar
Tedesco L, Valerio A, Cervino C, Cardile A, Pagano C, Vettor R, Pasquali R, Carruba MO, Marsicano G, Lutz B: Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes. 2008, 57: 2028-2036. 10.2337/db07-1623.
Article
Google Scholar
Verty AN, Allen AM, Oldfield BJ: The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure. Obesity(SilverSpring). 2009, 17: 254-261.
Google Scholar
Tedesco L, Valerio A, Dossena M, Cardile A, Ragni M, Pagano C, Pagotto U, Carruba MO, Vettor R, Nisoli E: Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. Diabetes. 2010, 59: 2826-2836. 10.2337/db09-1881.
Article
Google Scholar