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  1. α-Linolenic acid (ALA) is a plant-derived omega-3 unsaturated fatty acid that is rich in flaxseed oil (FO). The effect of FO on bone health is controversial. This study aims to evaluate the effect of FO on bon...

    Authors: Fulian Chen, Yan Wang, Hongwei Wang, Zhenhua Dong, Yan Wang, Mengqi Zhang, Jiaxuan Li, Shanshan Shao, Chunxiao Yu, Zhikun Huan and Jin Xu

    Citation: Nutrition & Metabolism 2019 16:71

    Content type: Research

    Published on:

  2. Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract bu...

    Authors: Chiao-Ming Chen, Chun-Kuang Shih, Yi-Jing Su, Kuan-Un Cheang, Shu-Fang Lo and Sing-Chung Li

    Citation: Nutrition & Metabolism 2019 16:70

    Content type: Research

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  3. Liver lipid accumulation induced by high-fat diet (HFD) is an early onset process of non-alcoholic fatty liver diseases (NAFLD). Protein kinase A (PKA) is known to be involved in hepatic lipid metabolism. Howe...

    Authors: Jining Yang, Xiaoying Zhang, Long Yi, Ling Yang, Wei Eric Wang, Chunyu Zeng, Mantian Mi and Xiongwen Chen

    Citation: Nutrition & Metabolism 2019 16:69

    Content type: Research

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  4. Apelin, as an adipokine, plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. This study aimed to determine whether the quality and quantity of dietary carbohydrates were asso...

    Authors: Emad Yuzbashian, Golaleh Asghari, Maryam Aghayan, Mehdi Hedayati, Maryam Zarkesh, Parvin Mirmiran and Alireza Khalaj

    Citation: Nutrition & Metabolism 2019 16:68

    Content type: Research

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  5. Normal distribution of body fluid is important for maintaining health through the balance of water metabolism. Studies have shown that disease states and diuretics perturb the balance and then induce abnormal ...

    Authors: Na Zhang, Jianfen Zhang, Songming Du, Hairong He, Xinyu Yan and Guansheng Ma

    Citation: Nutrition & Metabolism 2019 16:67

    Content type: Research

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  6. Current evidence remains equivocal as to whether and how consumption of coffee may be associated with risk of bladder cancer, and potential influence of confounding by smoking on this association is yet to be ...

    Authors: Zhi-Wei Dai, Ke-Dan Cai, Fu-Rong Li, Xian-Bo Wu and Guo-Chong Chen

    Citation: Nutrition & Metabolism 2019 16:66

    Content type: Research

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  7. A combination of resistance training and whey protein supplementation is a common practice among athletes and recreational exercisers to enhance muscle growth and strength. Although their safety as food additi...

    Authors: Yago Carvalho Lima, Mirian Ayumi Kurauti, Gabriel da Fonseca Alves, Jonathan Ferezini, Silvano Piovan, Ananda Malta, Fernanda Losi Alves de Almeida, Rodrigo Mello Gomes, Paulo Cezar de Freitas Mathias, Paula Gimenez Milani, Silvio Cláudio da Costa and Cecilia Edna Mareze-Costa

    Citation: Nutrition & Metabolism 2019 16:65

    Content type: Research

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  8. Both genetic and lifestyle factors contribute to the incidence of type 2 diabetes. It yet remains controversial whether and how alcohol consumption, one of the most prevalent lifestyle habits, influences type ...

    Authors: Hairong Yu, Tao Wang, Rong Zhang, Jing Yan, Feng Jiang, Shanshan Li, Weiping Jia and Cheng Hu

    Citation: Nutrition & Metabolism 2019 16:64

    Content type: Research

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  9. Obesity can lead to a chronic systemic inflammatory state that increases the risk of cancer development. Therefore, this study aimed to evaluate the alterations in tumor non-infiltrated lymphocytes function an...

    Authors: Cesar Miguel Momesso dos Santos, Vinicius Leonardo Sousa Diniz, André Luis Lacerda Bachi, Laiane Cristina dos Santos de Oliveira, Tamara Ghazal, Maria Elizabeth Pereira Passos, Heloisa Helena de Oliveira, Gilson Murata, Laureane Nunes Masi, Amanda Roque Martins, Adriana Cristina Levada-Pires, Rui Curi, Sandro Massao Hirabara, Donald F. Sellitti, Tania Cristina Pithon-Curi and Renata Gorjão

    Citation: Nutrition & Metabolism 2019 16:63

    Content type: Research

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  10. The WHO/UNICEF/ICCIDD define iodine deficiency during pregnancy as median urinary iodine concentration (MUIC) ≤ 150 μg/L. China implemented universal salt iodization (USI) in 1995, and recent surveillance show...

    Authors: Huidi Zhang, Meng Wu, Lichen Yang, Jinghuan Wu, Yichun Hu, Jianhua Han, Yunyou Gu, Xiuwei Li, Haiyan Wang, Liangkun Ma and Xiaoguang Yang

    Citation: Nutrition & Metabolism 2019 16:62

    Content type: Research

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  11. Organophosphorus pesticides (OP’s) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and anima...

    Authors: Edina da Luz Abreu, Anne Suély Pinto Savall, Allyson Ardais Boneberg, Bianca Barreto Martins, Vanessa Carratú Gervini, Tuane Bazanella Sampaio, André Ricardo Fajardo, Natália Paroul, Daniel Henrique Roos and Simone Pinton

    Citation: Nutrition & Metabolism 2019 16:61

    Content type: Research

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  12. Calorie restriction (CR) has been well proved to be a powerful tool to improve metabolic health associated with aging; and many types of CR have been proposed. Intermittent CR has become a trend in recent year...

    Authors: Siying Wei, Jingyu Zhao, Meijuan Bai, Chenchen Li, Lingling Zhang and Yan Chen

    Citation: Nutrition & Metabolism 2019 16:60

    Content type: Research

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  13. Elevated post-prandial blood glucose during pregnancy has been associated with adverse pregnancy and offspring outcomes, such as maternal gestational diabetes and excessive foetal growth. The ROLO Study is a r...

    Authors: Linda Marchioro, Aisling A. Geraghty, Olaf Uhl, Engy Shokry, Eileen C. O’Brien, Berthold Koletzko and Fionnuala M. McAuliffe

    Citation: Nutrition & Metabolism 2019 16:59

    Content type: Research

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  14. A carbohydrate-restricted (CR) diet can improve glycemic control in people with type 2 diabetes mellitus (T2DM). There are concerns, however, that the high dietary fat content of CR diets can increase low-dens...

    Authors: Ashley E. Mason, Laura R. Saslow, Patricia J. Moran, Sarah Kim, Hiba Abousleiman, Robert Richler, Samantha Schleicher, Veronica M. Goldman, Alison Hartman, Cindy Leung, Wendy Hartogensis and Frederick M. Hecht

    Citation: Nutrition & Metabolism 2019 16:58

    Content type: Research

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    The Correction to this article has been published in Nutrition & Metabolism 2019 16:91

  15. The rise in global obesity makes it crucial to understand how diet drives obesity-related health conditions, such as premature cognitive decline and Alzheimer’s disease (AD). In AD hippocampal-dependent episod...

    Authors: Fiona H. McLean, Fiona M. Campbell, Domenico Sergi, Christine Grant, Amanda C. Morris, Elizabeth A. Hay, Alasdair MacKenzie, Claus D. Mayer, Rosamund F. Langston and Lynda M. Williams

    Citation: Nutrition & Metabolism 2019 16:57

    Content type: Research

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  16. We previously demonstrated that improved net muscle protein balance, via enhanced protein synthetic efficiency, occurs 5 days after testosterone (T) administration. Whether the effects of T on muscle protein k...

    Authors: David D. Church, Stefan M. Pasiakos, Robert R. Wolfe and Arny A. Ferrando

    Citation: Nutrition & Metabolism 2019 16:56

    Content type: Brief communication

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  17. Iron nutrition is important for the health of women of reproductive age, and defining the physiologic requirement for iron can help them accurately plan the iron intake. However, research on the physiologic re...

    Authors: Jiaxi Lu, Jie Cai, Tongxiang Ren, Jinghuan Wu, Deqian Mao, Weidong Li, Yu Zhang, Jianhua Piao, Jun Wang, Lichen Yang, Xiaoguang Yang and Yuxia Ma

    Citation: Nutrition & Metabolism 2019 16:55

    Content type: Research

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  18. The prevalence of obesity and excessive gestational weight gain (GWG) has been increasing worldwide. The aims of this study were to evaluate associations of prepregnancy body mass index (BMI) and rate of GWG i...

    Authors: Xueyin Wang, Xiaosong Zhang, Min Zhou, Juan Juan and Xu Wang

    Citation: Nutrition & Metabolism 2019 16:54

    Content type: Research

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  19. Currently available treatments for colorectal cancer (CRC) associate with numerous side-effects that reduce patients’ quality of life. The effective nutraceuticals with high anti-proliferative efficacy and low...

    Authors: Abilasha Gayani Jayathilake, Elif Kadife, Rodney Brain Luwor, Kulmira Nurgali and Xiao Qun Su

    Citation: Nutrition & Metabolism 2019 16:53

    Content type: Research

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  20. The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid...

    Authors: Shilong Xiang, Xiaohui Zhang, Xishao Xie, Junni Wang, Qin Zhou, Zhimin Chen, Yaomin Wang, Guangjun Liu, Fei Han and Jianghua Chen

    Citation: Nutrition & Metabolism 2019 16:52

    Content type: Research

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  21. Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfuncti...

    Authors: Irena Markova, Martina Hüttl, Olena Oliyarnyk, Tereza Kacerova, Martin Haluzik, Petr Kacer, Ondrej Seda and Hana Malinska

    Citation: Nutrition & Metabolism 2019 16:51

    Content type: Research

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  22. Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lip...

    Authors: Yunxia Zhu, Xiaoyan Zhang, Li Zhang, Mingliang Zhang, Ling Li, Deng Luo and Yuan Zhong

    Citation: Nutrition & Metabolism 2019 16:50

    Content type: Research

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  23. Plant-based food medicine and functional foods have been consumed extensively due to their bioactive substances and health-beneficial effects. Vinegar is one of them due to its bioactivities, which confers ben...

    Authors: Nurul Elyani Mohamad, Nadiah Abu, Swee Keong Yeap, Kian Lam Lim, Muhammad Firdaus Romli, Shaiful Adzni Sharifuddin, Kamariah Long and Noorjahan Banu Alitheen

    Citation: Nutrition & Metabolism 2019 16:49

    Content type: Research

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  24. Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction sig...

    Authors: Yoo Kim, Michael Rouse, Isabel González-Mariscal, Josephine M. Egan and Jennifer F. O’Connell

    Citation: Nutrition & Metabolism 2019 16:48

    Content type: Research

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  25. Flavonoids are a class of plant and fungus secondary metabolites and are the most common group of polyphenolic compounds in the human diet. In recent studies, flavonoids have been shown to induce browning of w...

    Authors: Xuejun Zhang, Xin Li, Huang Fang, Fengjin Guo, Feng Li, Anmin Chen and Shilong Huang

    Citation: Nutrition & Metabolism 2019 16:47

    Content type: Review

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  26. There is a growing interest in the pathopysiological consequences of postprandial hyperglycemia. It is well known that in diabetic patients 2 h plasma glucose is a better risk predictor for coronary heart dise...

    Authors: María González-Rodríguez, Marcos Pazos-Couselo, José M. García-López, Santiago Rodríguez-Segade, Javier Rodríguez-García, Carmen Túñez-Bastida and Francisco Gude

    Citation: Nutrition & Metabolism 2019 16:46

    Content type: Research

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  27. Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new...

    Authors: Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi and Shimpei Ushio

    Citation: Nutrition & Metabolism 2019 16:45

    Content type: Research

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  28. Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between viscer...

    Authors: Xiaohui Guo, Yifan Xu, Hairong He, Hao Cai, Jianfen Zhang, Yibin Li, Xinyu Yan, Man Zhang, Na Zhang, Rolando L. Maddela and Guansheng Ma

    Citation: Nutrition & Metabolism 2019 16:44

    Content type: Research

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  29. The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resist...

    Authors: Tomomi Sano, Taiki Sanada, Yusuke Sotomaru, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Takashi Kanematsu and Fusanori Nishimura

    Citation: Nutrition & Metabolism 2019 16:43

    Content type: Research

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  30. Endothelial oxidative injury is a key event in the pathogenesis of atherosclerosis (AS). Resveratrol (RSV) attenuates the oxidative injury in human umbilical vein endothelial cells (HUVECs). Autophagy is criti...

    Authors: Xi Zhou, Jining Yang, Min Zhou, Yu Zhang, Yang Liu, Pengfei Hou, Xianglong Zeng, Long Yi and Mantian Mi

    Citation: Nutrition & Metabolism 2019 16:42

    Content type: Research

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  31. Apolipoprotein A-IV (ApoA-IV) exists in relatively high levels in the circulation systems of animals, but its roles are not fully elucidated. It is known that the Apoa4 gene resides in the cluster Apoa1/Apoc3/Apo...

    Authors: Zhenguo Wang, Lu Wang, Zhuzhen Zhang, Li Feng, Xue Song and Jiarui Wu

    Citation: Nutrition & Metabolism 2019 16:41

    Content type: Research

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  32. As reported previously by our group, medium-chain triglycerides can ameliorate atherosclerosis. Given that TLR4 is closely related to atherosclerosis, we hypothesized herein that caprylic acid (C8:0) would sup...

    Authors: Xinsheng Zhang, Changyong Xue, Qing Xu, Yong Zhang, Huizi Li, Feng Li, Yinghua Liu and Changjiang Guo

    Citation: Nutrition & Metabolism 2019 16:40

    Content type: Research

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  33. Long non-coding RNAs (lncRNAs) are involved in numerous physiological functions. Yet, their mechanisms in coronary artery disease (CAD) are not well understood.

    Authors: Liu Miao, Rui-Xing Yin, Qing-Hui Zhang, Xi-Jiang Hu, Feng Huang, Wu-Xian Chen, Xiao-Li Cao and Jin-Zhen Wu

    Citation: Nutrition & Metabolism 2019 16:39

    Content type: Research

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  34. The incidence of metabolic syndrome linked to dyslipidemia and insulin resistance has increased; thus, studies must be conducted to elucidate this phenomenon. The present study aimed to investigate the protect...

    Authors: Oeuk Jeong and Hyun-Sook Kim

    Citation: Nutrition & Metabolism 2019 16:38

    Content type: Research

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  35. Proliferative diabetic retinopathy (PDR), a sight-threatening retinopathy, is the leading cause of irreversible blindness in adults. Despite strict control of systemic risk factors, a fraction of patients with...

    Authors: Xiao-Rong Zhu, Fang-yuan Yang, Jing Lu, Hui-rong Zhang, Ran Sun, Jian-Bo Zhou and Jin-Kui Yang

    Citation: Nutrition & Metabolism 2019 16:37

    Content type: Research

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  36. High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development...

    Authors: Kuen-Ming Wu, Yuan-Man Hsu, Mei-Chin Ying, Fuu-Jen Tsai, Chang-Hai Tsai, Jing-Gung Chung, Jai-Sing Yang, Chih-Hsin Tang, Li-Yi Cheng, Po-Hua Su, Vijaya Padma Viswanadha, Wei-Wen Kuo and Chih-Yang Huang

    Citation: Nutrition & Metabolism 2019 16:36

    Content type: Research

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  38. Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to det...

    Authors: Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang and Xiaoqing Tang

    Citation: Nutrition & Metabolism 2019 16:34

    Content type: Research

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  39. Cutaneous malignant melanoma is a heterogeneous disease, being the consequence of specific genetic alterations along several molecular pathways. Despite the increased knowledge about the biology and pathogenes...

    Authors: Maria Neve Ombra, Panagiotis Paliogiannis, Luigia Stefania Stucci, Maria Colombino, Milena Casula, Maria Cristina Sini, Antonella Manca, Grazia Palomba, Ignazio Stanganelli, Mario Mandalà, Sara Gandini, Amelia Lissia, Valentina Doneddu, Antonio Cossu and Giuseppe Palmieri

    Citation: Nutrition & Metabolism 2019 16:33

    Content type: Review

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  40. Adipogenesis, the process of preadipocyte differentiation to mature adipocytes accompanied by accumulation of intracytoplasmic lipid droplets, is regulated by various genetic and environmental factors, and clo...

    Authors: Yusuke Ando, Fumiaki Sato, Hazuki Fukunaga, Yusuke Iwasaki, Yoshihiko Chiba, Masahiko Tebakari, Yuki Daigo, Junichi Kawashima and Junzo Kamei

    Citation: Nutrition & Metabolism 2019 16:32

    Content type: Research

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  41. Obesity increases the risk of metabolic dysfunction such as dyslipidemia, hypertension, and fatty liver. Physcion (PY) is an anthraquinone that reportedly has anti-inflammatory and anti-bacterial properties. H...

    Authors: Seon-Jeong Lee, Su-Jung Cho, Eun-Young Kwon and Myung-Sook Choi

    Citation: Nutrition & Metabolism 2019 16:31

    Content type: Research

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  42. Several biomarkers are used to measure iron deficiency (ID) during pregnancy, but the prevalence of ID and its association with adverse birth outcomes shows inconsistent results. The aim of this study was to e...

    Authors: Xiaosong Yuan, Huiwen Hu, Ming Zhang, Wei Long, Jianbing Liu, Jian Jiang and Bin Yu

    Citation: Nutrition & Metabolism 2019 16:30

    Content type: Research

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  43. It is not clear whether the frequently reported phenomenon of exercise-induced anorexia is exacerbated or blunted in warm or cold environments. Therefore, this study investigated the effects of exercise in thr...

    Authors: Iva Mandic, Mavra Ahmed, Shawn Rhind, Len Goodman, Mary L’Abbe and Ira Jacobs

    Citation: Nutrition & Metabolism 2019 16:29

    Content type: Research

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  44. This study aimed to assess the potential effects of long-term intake of caffeine and habitual consumption of coffee and tea on the occurrence of cardio-renal events among an Iranian population with low coffee ...

    Authors: Zahra Gaeini, Zahra Bahadoran, Parvin Mirmiran and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2019 16:28

    Content type: Research

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  45. Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type...

    Authors: Luting Wu, Li Ran, Hedong Lang, Min Zhou, Li Yu, Long Yi, Jundong Zhu, Lei Liu and Mantian Mi

    Citation: Nutrition & Metabolism 2019 16:27

    Content type: Research

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  46. Prolonged over-consumption of a high-fat diet (HFD) commonly leads to obesity and insulin resistance. However, even 3 days of HFD consumption has been linked to inflammation within the key homeostatic brain re...

    Authors: Fiona H. McLean, Fiona M. Campbell, Rosamund F. Langston, Domenico Sergi, Cibell Resch, Christine Grant, Amanda C. Morris, Claus D. Mayer and Lynda M. Williams

    Citation: Nutrition & Metabolism 2019 16:26

    Content type: Research

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  47. Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood. In this study, we examin...

    Authors: Zhe Meng, Mengyu Wang, Junhui Xing, Yuzhou Liu and Haiyu Li

    Citation: Nutrition & Metabolism 2019 16:25

    Content type: Research

    Published on:

  48. Consumption of diet high in soy products is suggested to contribute to lower prostate cancer incidence in Asian men. But little has been known about the influences of dietary patterns on gut microbiota and mic...

    Authors: Yufei Liu, Xiaobo Wu and Haowen Jiang

    Citation: Nutrition & Metabolism 2019 16:24

    Content type: Research

    Published on:

  49. The process of atherosclerosis begins early in childhood and usually remains asymptomatic until later in life. Carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis could identify ea...

    Authors: Maryam Aghayan, Golaleh Asghari, Emad Yuzbashian, Pooneh Dehghan, Hossein Khadem Haghighian, Parvin Mirmiran and Maryam Javadi

    Citation: Nutrition & Metabolism 2019 16:23

    Content type: Research

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  50. Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in obesity-related diseases such as type 2 diabetes. The effects of SIRT1 on integration of metabolism and inflammation may p...

    Authors: Hung-Wen Liu, Hao-Han Kao and Chi-Hang Wu

    Citation: Nutrition & Metabolism 2019 16:22

    Content type: Research

    Published on:

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