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  1. Content type: Research

    Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and homocystein...

    Authors: Nayoung Han, Jung-woo Chae, Jihyun Jeon, Jaeyeon Lee, Hyun-moon Back, Byungjeong Song, Kwang-il Kwon, Sang Kyum Kim and Hwi-yeol Yun

    Citation: Nutrition & Metabolism 2018 15:14

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  2. Content type: Review

    Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D h...

    Authors: Shahida Khan, Ashraf Ali, Sarah Khan, Ahmed Bakillah, Ghazi Damanhouri, Aziz Khan, Ahmed Makki, Ibtehal AlAnsari and Naheed Banu

    Citation: Nutrition & Metabolism 2018 15:13

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    The Correction to this article has been published in Nutrition & Metabolism 2018 15:21

  3. Content type: Research

    Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. Curcumin (Cur), a possible anti...

    Authors: Taiki Miyazawa, Kiyotaka Nakagawa, Sharon H. Kim, Michael J. Thomas, Ligi Paul, Jean-Marc Zingg, Gregory G. Dolnikowski, Susan B. Roberts, Fumiko Kimura, Teruo Miyazawa, Angelo Azzi and Mohsen Meydani

    Citation: Nutrition & Metabolism 2018 15:12

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  4. Content type: Research

    Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role...

    Authors: Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J. Mendez, Vivek K. Vishnudas, Rangaprasad Sarangarajan and Niven R. Narain

    Citation: Nutrition & Metabolism 2018 15:11

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  5. Content type: Research

    The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit mitochondrial β-oxidation, and can be used as chemically induced hepatic steatosis-model in rodents, while 3-thia fatty acid tetrade...

    Authors: Bodil Bjørndal, Eva Katrine Alterås, Carine Lindquist, Asbjørn Svardal, Jon Skorve and Rolf K. Berge

    Citation: Nutrition & Metabolism 2018 15:10

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  6. Content type: Review

    The aim of this systematic review was to assess the effect of fructo-oligosaccharide supplementation on glucose homeostasis. The search process was based on the selection of publications listed in the Pubmed-M...

    Authors: Cindy Le Bourgot, Emmanuelle Apper, Sophie Blat and Frédérique Respondek

    Citation: Nutrition & Metabolism 2018 15:9

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  7. Content type: Research

    Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few studies have indicated that polysaccharides improve obesity by regulating the metabolism o...

    Authors: Mingyi Chen, Biyu Lu, Yuan Li, Yuanyuan Wang, Haihui Zheng, Danmin Zhong, Ziqiong Liao, Mengxia Wang, Fangli Ma, Qiongfeng Liao and Zhiyong Xie

    Citation: Nutrition & Metabolism 2018 15:8

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  8. Content type: Research

    Selenoprotein F (SELENOF, was named as 15-kDa selenoprotein) has been reported to play important roles in oxidative stress, endoplasmic reticulum (ER) stress and carcinogenesis. However, the biological functio...

    Authors: Jing Tian, Jiapan Liu, Jieqiong Li, Jingxin Zheng, Lifang Chen, Yujuan Wang, Qiong Liu and Jiazuan Ni

    Citation: Nutrition & Metabolism 2018 15:7

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  9. Content type: Review

    Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as st...

    Authors: Nardev Ramanathan, Esther Tan, Li Jun Loh, Boon Seng Soh and Wei Ney Yap

    Citation: Nutrition & Metabolism 2018 15:6

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  10. Content type: Research

    The relationship between low iodine status and pregnancy-associated comorbidities has been known for decades. The relationship between iodine intake and placental pathologies is, however, far less clear. This ...

    Authors: Julie Bienertová-Vašků, Markéta Grulichová, Ondřej Mikeš, Filip Zlámal, Tomáš Pruša, Aneta Pohořalá, Lenka Andrýsková and Hynek Pikhart

    Citation: Nutrition & Metabolism 2018 15:5

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  11. Content type: Research

    During inflammation, immune cells produce cytokines, chemokines and prostaglandins. This results in acute or chronic inflammation, which favor the development of degenerative diseases such as diabetes, obesity...

    Authors: Joseph Schwager, Lidia Gagno, Nathalie Richard, Werner Simon, Peter Weber and Igor Bendik

    Citation: Nutrition & Metabolism 2018 15:4

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  12. Content type: Perspective

    Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat gr...

    Authors: Michael A. Pellizzon and Matthew R. Ricci

    Citation: Nutrition & Metabolism 2018 15:3

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    The Correction to this article has been published in Nutrition & Metabolism 2018 15:23

  13. Content type: Research

    Recently, supplementation of L-carnitine to obese rats was found to improve the carnitine status and to counteract an obesity-induced muscle fiber transition from type I to type II. However, it has not been re...

    Authors: Daniel Kaup, Janine Keller, Erika Most, Joachim Geyer, Klaus Eder and Robert Ringseis

    Citation: Nutrition & Metabolism 2018 15:2

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  14. Content type: Research

    Short sleep duration has been related to established cardiovascular risk factors, likely obesity, diabetes, hypertension and dyslipidaemia. However, to the best of our knowledge, the associations between sleep...

    Authors: Huihui Ren, Zhelong Liu, Xinrong Zhou and Gang Yuan

    Citation: Nutrition & Metabolism 2018 15:1

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  15. Content type: Research

    This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM)...

    Authors: Maryamalsadat Razavi, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Mohsen Taghizadeh, Reza Bekhradi, Elahe Seyed Hosseini, Hamed Haddad Kashani, Maryam Karamali and Zatollah Asemi

    Citation: Nutrition & Metabolism 2017 14:80

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  16. Content type: Research

    Type VI collagen is supposed to be a regulation factor in adipogenesis. This study aimed to assess the promoting effect of vitamin C (VC) on adipogenic differentiation of preadipocytes as well as its mechanism.

    Authors: Chuanguo Liu, Kun Huang, Guorong Li, Pingping Wang, Chang Liu, Congcong Guo, Zongguo Sun and Jie Pan

    Citation: Nutrition & Metabolism 2017 14:79

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  17. Content type: Review

    An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia...

    Authors: Avinash Kumar, Henry A. Palfrey, Rashmi Pathak, Philip J. Kadowitz, Thomas W. Gettys and Subramanyam N. Murthy

    Citation: Nutrition & Metabolism 2017 14:78

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  18. Content type: Review

    Data on diet–genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet ...

    Authors: Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S. Daneshpour, Bahar Sedaghati-Khayat and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2017 14:77

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  19. Content type: Correction

    Following publication of the original article [1], the authors requested a correction to the name of one of the co-authors. The correct name and spelling is V.V. Sathibabu Uddandrao.

    Authors: Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy and V. V. Sathibabu Uddandrao

    Citation: Nutrition & Metabolism 2017 14:76

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    The original article was published in Nutrition & Metabolism 2017 14:72

  20. Content type: Brief communication

    Dietary docosahexaenoic acid (DHA, 22:6n-3) not only increases blood and tissue levels of DHA, but also eicosapentaenoic acid (EPA, 20:5n-3). It is generally believed that this increase is due to DHA retroconv...

    Authors: Adam H. Metherel, Raphaël Chouinard-Watkins, Marc-Olivier Trépanier, R. J. Scott Lacombe and Richard P. Bazinet

    Citation: Nutrition & Metabolism 2017 14:75

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  22. Content type: Research

    The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting bl...

    Authors: Shihui Fu, Rongjie Jin, Leiming Luo and Ping Ye

    Citation: Nutrition & Metabolism 2017 14:73

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  23. Content type: Research

    Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat ...

    Authors: Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy and V. V. Sathibabu Uddandrao

    Citation: Nutrition & Metabolism 2017 14:72

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    The Correction to this article has been published in Nutrition & Metabolism 2017 14:76

  24. Content type: Research

    Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body. Th...

    Authors: Klaus Eder, Marina Siebers, Erika Most, Susan Scheibe, Norbert Weissmann and Denise K. Gessner

    Citation: Nutrition & Metabolism 2017 14:71

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  25. Content type: Research

    To establish Japanese children’s estimated energy requirements, total energy expenditure (TEE) data measured using the doubly labeled water (DLW) method is needed. This study aimed to 1) obtain basic TEE data ...

    Authors: Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura and Kojiro Ishii

    Citation: Nutrition & Metabolism 2017 14:70

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  26. Content type: Research

    NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations....

    Authors: Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski and Karolina Konstantynowicz-Nowicka

    Citation: Nutrition & Metabolism 2017 14:69

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  27. Content type: Research

    Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and car...

    Authors: Wei Li, Renqiao Tang, Shengrong Ouyang, Feifei Ma, Zhuo Liu and Jianxin Wu

    Citation: Nutrition & Metabolism 2017 14:68

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  28. Content type: Research

    This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2).

    Authors: Yan-Hong Huang, Ting-Ting Ye, Chong-Xiao Liu, Lei Wang, Yuan-Wen Chen and Yan Dong

    Citation: Nutrition & Metabolism 2017 14:67

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  29. Content type: Research

    High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal muc...

    Authors: Octave Mucunguzi, Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, André Boivin, Ezequiel-Luis Calvo and Jonny St-Amand

    Citation: Nutrition & Metabolism 2017 14:66

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  30. Content type: Research

    Toll-like receptor 4 (TLR4), an innate immune receptor, is suspected to play a key role in the postprandial inflammation that is induced by a high-fat meal rich in saturated fatty acids (SFA). Our objective wa...

    Authors: Dominique Hermier, Véronique Mathé, Annaïg Lan, Clélia Santini, Annie Quignard-Boulangé, Jean-François Huneau and François Mariotti

    Citation: Nutrition & Metabolism 2017 14:65

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  31. Content type: Research

    The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio an...

    Authors: Li Zhao, Jing Cheng, Yingchao Chen, Qin Li, Bing Han, Yi Chen, Fangzhen Xia, Chi Chen, Dongping Lin, Xuemei Yu, Ningjian Wang and Yingli Lu

    Citation: Nutrition & Metabolism 2017 14:64

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  32. Content type: Research

    Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between ...

    Authors: Yeli Wang, Woon-Puay Koh, Jian-Min Yuan and An Pan

    Citation: Nutrition & Metabolism 2017 14:63

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  33. Content type: Research

    To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosa...

    Authors: Paula A. Lopes, Narcisa M. Bandarra, Susana V. Martins, Joana Martinho, Cristina M. Alfaia, Marta S. Madeira, Carlos Cardoso, Cláudia Afonso, Maria C. Paulo, Rui M. A. Pinto, José L. Guil-Guerrero and José A. M. Prates

    Citation: Nutrition & Metabolism 2017 14:62

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  34. Content type: Reaearch

    Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid...

    Authors: Arrigo F.G. Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D’Addato and Claudio Borghi

    Citation: Nutrition & Metabolism 2017 14:61

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    The Correction to this article has been published in Nutrition & Metabolism 2018 15:44

  35. Content type: Review

    Although the regular consumption of resveratrol has been known to improve glucose homeostasis and reverse insulin resistance in type 2 diabetes mellitus (T2DM), the reported results are inconsistent. Thus, we ...

    Authors: Xiangyun Zhu, Chunhua Wu, Shanhu Qiu, Xuelu Yuan and Ling Li

    Citation: Nutrition & Metabolism 2017 14:60

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  36. Content type: Research

    Previously, we reported that a low-protein diet significantly reduced insulin secretion in response to feeding within 1 h in rats, suggesting that the insulinotropic effect of dietary protein plays an importan...

    Authors: Mami Horiuchi, Tomoya Takeda, Hiroyuki Takanashi, Yori Ozaki-Masuzawa, Yusuke Taguchi, Yuka Toyoshima, Lila Otani, Hisanori Kato, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka

    Citation: Nutrition & Metabolism 2017 14:59

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  37. Content type: Research

    Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in m...

    Authors: Christopher Papandreou, Mònica Bullò, Francisco José Tinahones, Miguel Ángel Martínez-González, Dolores Corella, Georgios A. Fragkiadakis, José López-Miranda, Ramon Estruch, Montserrat Fitó and Jordi Salas-Salvadó

    Citation: Nutrition & Metabolism 2017 14:58

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  38. Content type: Research

    The aim of the study was to assess both patients’ and their parents’ knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet.

    Authors: Ewa Witalis, Bozena Mikoluc, Radoslaw Motkowski, Jolanta Sawicka-Powierza, Agnieszka Chrobot, Bozena Didycz, Agata Lange, Renata Mozrzymas, Andrzej Milanowski, Maria Nowacka, Mariola Piotrowska-Depta, Hanna Romanowska, Ewa Starostecka, Jolanta Wierzba, Magdalena Skorniewska, Barbara Iwona Wojcicka-Bartlomiejczyk…

    Citation: Nutrition & Metabolism 2017 14:57

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  39. Content type: Research

    Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatit...

    Authors: Lili Chen, Xiaolong Zhao, Guangjun Liang, Jiuru Sun, Zhifeng Lin, Renming Hu, Peili Chen, Zhaoyun Zhang, Linuo Zhou and Yiming Li

    Citation: Nutrition & Metabolism 2017 14:56

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  41. Content type: Research

    Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingest...

    Authors: Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu and Guiju Sun

    Citation: Nutrition & Metabolism 2017 14:54

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  42. Content type: Research

    Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigat...

    Authors: Lu Lei, Kejia Li, Ling Li, Xia Fang, Tingting Zhou, Cheng Zhang, Yong Luo, Hua Liu, Xiaoqiang Li, Hongting Zheng, Lin Zhang, Gangyi Yang and Lin Gao

    Citation: Nutrition & Metabolism 2017 14:53

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  43. Content type: Research

    Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were rep...

    Authors: Jia Song, Cheng Li, Yushan Lv, Yi Zhang, William Kwame Amakye and Limei Mao

    Citation: Nutrition & Metabolism 2017 14:52

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  44. Content type: Research

    Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared...

    Authors: Chiao-Ming Chen, Jen-Fang Liu, Sing-Chung Li, Chen-Ling Huang, An-Tsz Hsirh, Shuen-Fu Weng, Mei-Ling Chang, Hung-Ta Li, Emily Mohn and C-Y. Oliver Chen

    Citation: Nutrition & Metabolism 2017 14:51

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  45. Content type: Research

    Vitamin D status and season are intrinsically linked, and both have been proposed to be associated with glucose homeostasis in pregnancy, with conflicting results. We aimed to determine if exposure to winter a...

    Authors: Eileen C. O’Brien, Elizabeth J. O’Sullivan, Mark T. Kilbane, Aisling A. Geraghty, Malachi J. McKenna and Fionnuala M. McAuliffe

    Citation: Nutrition & Metabolism 2017 14:50

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  46. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD), recognized as the liver manifestation of metabolic syndrome, is highly prevalent in the general population. Recent studies suggest that lipid accumulation product is ...

    Authors: Haijiang Dai, Weijun Wang, Ruifang Chen, Zhiheng Chen, Yao Lu and Hong Yuan

    Citation: Nutrition & Metabolism 2017 14:49

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  47. Content type: Research

    Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse ce...

    Authors: Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman and Sung Hoon Back

    Citation: Nutrition & Metabolism 2017 14:48

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  48. Content type: Review

    Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixe...

    Authors: Nicole M. Delimont, Sara K. Rosenkranz, Mark D. Haub and Brian L. Lindshield

    Citation: Nutrition & Metabolism 2017 14:47

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  49. Content type: Research

    Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR).

    Authors: Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang and Xin-Hua Yin

    Citation: Nutrition & Metabolism 2017 14:46

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  50. Content type: Review

    Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development o...

    Authors: Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw and Rabia Johnson

    Citation: Nutrition & Metabolism 2017 14:45

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