Yedavally-Yellayi S, Ho AM, Patalinghug EM. Update on osteoporosis. Prim Care. 2019;46:175–90.
Tian L, Yu X. Fat, sugar, and bone health: a complex relationship. Nutrients. 2017;9.
Tomlinson DJ, Erskine RM, Morse CI, Onambele GL. Body fat percentage, body mass index, fat mass index and the ageing bone: their singular and combined roles linked to physical activity and diet. Nutrients. 2019;11.
Devlin MJ, Robbins A, Cosman MN, Moursi CA, Cloutier AM, Louis L, Van Vliet M, Conlon C, Bouxsein ML. Differential effects of high fat diet and diet-induced obesity on skeletal acquisition in female C57BL/6J vs. FVB/NJ Mice Bone Rep. 2018;8:204–14.
Picke AK, Sylow L, Moller LLV, Kjobsted R, Schmidt FN, Steejn MW, Salbach-Hirsch J, Hofbauer C, Bluher M, Saalbach A, et al. Differential effects of high-fat diet and exercise training on bone and energy metabolism. Bone. 2018;116:120–34.
Alsahli A, Kiefhaber K, Gold T, Muluke M, Jiang H, Cremers S, Schulze-Spate U. Palmitic acid reduces circulating bone formation markers in obese animals and impairs osteoblast activity via C16-ceramide accumulation. Calcif Tissue Int. 2016;98:511–9.
Rodrigues CF, Salgueiro W, Bianchini M, Veit JC, Puntel RL, Emanuelli T, Dernadin CC, Avila DS: Salvia hispanica L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in Caenorhabditis elegans
. Nutr Metab (Lond) 2018, 15:83.
Abdelhamid AS, Martin N, Bridges C, Brainard JS, Wang X, Brown TJ, Hanson S, Jimoh OF, Ajabnoor SM, Deane KH, et al. Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;7 Cd012345.
Montes Chani EM, Pacheco SOS, Martinez GA, Freitas MR, Ivona JG, Ivona JA, Craig WJ, Pacheco FJ. Long-term dietary intake of chia seed is associated with increased bone mineral content and improved hepatic and intestinal morphology in Sprague-Dawley rats. Nutrients. 2018;10.
Saini RK, Keum YS. Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance - a review. Life Sci. 2018;203:255–67.
Lavado-Garcia J, Roncero-Martin R, Moran JM, Pedrera-Canal M, Aliaga I, Leal-Hernandez O, Rico-Martin S, Canal-Macias ML. Long-chain omega-3 polyunsaturated fatty acid dietary intake is positively associated with bone mineral density in normal and osteopenic Spanish women. PLoS One. 2018;13:e0190539.
Wauquier F, Barquissau V, Leotoing L, Davicco MJ, Lebecque P, Mercier S, Philippe C, Miot-Noirault E, Chardigny JM, Morio B, et al. Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis. Bone. 2012;50:553–61.
Azuma MM, Gomes-Filho JE, Ervolino E, Pipa CB, Cardoso CBM, Andrada AC, Kawai T, Cintra LTA. Omega 3 fatty acids reduce bone resorption while promoting bone generation in rat apical periodontitis. J Endod. 2017;43:970–6.
Nakanishi A, Iitsuka N, Tsukamoto I. Fish oil suppresses bone resorption by inhibiting osteoclastogenesis through decreased expression of M-CSF, PU.1, MITF and RANK in ovariectomized rats. Mol Med Rep. 2013;7:1896–903.
Mirfatahi M, Imani H, Tabibi H, Nasrollahi A, Hedayati M. effects of flaxseed oil on serum bone turnover markers in in hemodialysis patients a randomized controlled trial. Iranian Journal of Kidney Diseases. 2018;12:215–22.
Ribeiro DC, Pereira AD, de Santana FC, Mancini-Filho J, da Silva EM, da Costa CA, Boaventura GT. Incorporation of flaxseed flour as a dietary source for ALA increases bone density and strength in post-partum female rats. Lipids. 2017;52:327–33.
Longo AB, Ward WE. Providing flaxseed oil but not menhaden oil protects against OVX induced bone loss in the mandible of Sprague-Dawley rats. Nutrients. 2016;8.
Cohen SL, Ward WE. Flaxseed oil and bone development in growing male and female mice. J Toxicol Environ Health A. 2005;68:1861–70.
Longo AB, Sullivan PJ, Peters SJ, LeBlanc PJ, Wohl GR, Ward WE. Lifelong intake of flaxseed or menhaden oil to provide varying n-6 to n-3 PUFA ratios modulate bone microarchitecture during growth, but not after OVX in Sprague-Dawley rats. Mol Nutr Food Res. 2017;61.
Turner CH, Burr DB. <basic biomechanical measurements of bone>. Bone. 1993;14:595–608.
Yi XJ, Li JC, Wang SY, Yan MY, Cui J, Pei LP. effect of Aralia echinocaulis containing serum on Wnt/beta-catenin signaling pathway of primary osteoblast. Zhongguo Zhong Yao Za Zhi. 2017;42:2749–53.
Liang D, Wang KJ, Tang ZQ, Liu RH, Zeng F, Cheng MY, Lian QS, Wu HK. Effects of nicotine on the metabolism and gene expression profile of SpragueDawley rat primary osteoblasts. Mol Med Rep. 2018;17:8269–81.
Bredella MA, Lin E, Gerweck AV, Landa MG, Thomas BJ, Torriani M, Bouxsein ML, Miller KK. Determinants of bone microarchitecture and mechanical properties in obese men. J Clin Endocrinol Metab. 2012;97:4115–22.
Aslam MN, Jepsen KJ, Khoury B, Graf KH, Varani J. Bone structure and function in male C57BL/6 mice: effects of a high-fat Western-style diet with or without trace minerals. Bone Rep. 2016;5:141–9.
Gautam J, Choudhary D, Khedgikar V, Kushwaha P, Singh RS, Singh D, Tiwari S, Trivedi R. Micro-architectural changes in cancellous bone differ in female and male C57BL/6 mice with high-fat diet-induced low bone mineral density. Br J Nutr. 2014;111:1811–21.
Shimano H. Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout. Prog Lipid Res. 2012;51:267–71.
Ussher JR. The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy. Expert Rev Cardiovasc Ther. 2014;12:345–58.
Guebre-Egziabher F, Alix PM, Koppe L, Pelletier CC, Kalbacher E, Fouque D, Soulage CO. Ectopic lipid accumulation: a potential cause for metabolic disturbances and a contributor to the alteration of kidney function. Biochimie. 2013;95:1971–9.
Symons JD, Abel ED. Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord. 2013;14:59–68.
Cao JJ, Gregoire BR, Gao H. High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone. 2009;44:1097–104.
Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA. Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone. 2013;57:174–83.
Cherukupalli K, Larson JE, Puterman M, Sekhon HS, Thurlbeck WM. Comparative biochemistry of gestational and postnatal lung growth and development in the rat and human. Pediatr Pulmonol. 1997;24:12–21.
Song J, Jing Z, Hu W, Yu J, Cui X. α-linolenic acid inhibits receptor activator of NF-κB ligand induced (RANKL-induced) Osteoclastogenesis and prevents inflammatory bone loss via downregulation of nuclear factor-KappaB-inducible nitric oxide synthases (NF-κB-iNOS) signaling pathways. Med Sci Monit. 2017;23:5056–69.
Nakanishi A, Tsukamoto I. n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARgamma-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARgamma-dependent inhibition of NFkB activation. J Nutr Biochem. 2015;26:1317–27.
Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab. 2009;27:265–71.
Meng J, Ma X, Wang N, Jia M, Bi L, Wang Y, Li M, Zhang H, Xue X, Hou Z, et al. Activation of GLP-1 receptor promotes bone marrow stromal cell osteogenic differentiation through beta-catenin. Stem Cell Reports. 2016;6:579–91.
Krishnan V, Bryant HU, Macdougald OA. Regulation of bone mass by Wnt signaling. J Clin Invest. 2006;116:1202–9.
Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem. 2005;280:21162–8.
Bruderer M, Richards RG, MAaMJ S, ARI D, Platz D. Switzerland: ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS. European Cells and Materials. 2014;28:269–86.
Franceschi RT, Xiao G. Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003;88:446–54.
Chen Y, Hu Y, Yang L, Zhou J, Tang Y, Zheng L, Qin P. Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K/AKT/GSK3beta/beta-catenin pathway. Cell Biol Int. 2017;41:822–32.
Lee DS, Roh SY, Park JC. The Nfic-osterix pathway regulates ameloblast differentiation and enamel formation. Cell Tissue Res. 2018;374:531–40.
Casado-Diaz A, Ferreiro-Vera C, Priego-Capote F, Dorado G, Luque-de-Castro MD, Quesada-Gomez JM. Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts. Genes Nutr. 2014;9:375.